The modern aspects of pharmacotherapy of chronic venous insufficiency (CVI) of the lower extremities are presented in the article. Phlebotropic drugs are medications for basic pharmacotherapy of CVI. A common characteristic of pharmacodynamics of these drugs is the ability to increase the venous tone, and reduce severity of specific symptoms and syndromes of CVI. The efficiency of the most wide...

PURPOSE Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide. METHODS ...

The aim of this study was to assess the medical treatment in comparison with hemorrhoidectomy in the management of primary grade-4 internal hemorrhoidal disease (IH) and external hemorrhoidal disease (CH). Group I (medical treatment): 127 patients (59 IH, 68 CH) were prospectively collected and medically treated using oral tablet of micronized purified flavonoid fraction (MPFF) containing 450 m...

Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders and inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the current work is to evaluate its benefits and phytochemicals related to those beneficial properties. A distinct polyphenol profile between P. tridenta...

We have tested 33 flavonoids, occurring ubiquitously in foods of plant origin, for their ability to alter the transport of the beta-lactam antibiotic cefixime via the H+-coupled intestinal peptide transporter PEPT1 in the human intestinal epithelial cell line Caco-2. Of the flavonoids tested, quercetin, genistein, naringin, diosmin, acacetin, and chrysin increased uptake of [14C]cefixime dose d...

Glycogen synthase kinase 3 (GSK-3) dysregulation is implicated in the two Alzheimer's disease (AD) pathological hallmarks: beta-amyloid plaques and neurofibrillary tangles. GSK-3 inhibitors may abrogate AD pathology by inhibiting amyloidogenic gamma-secretase cleavage of amyloid precursor protein (APP). Here, we report that the citrus bioflavonoid luteolin reduces amyloid-beta (Abeta) peptide g...

Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (...

Diosmetin (3', 5, 7-trihydroxy-4'-methoxyflavone), the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit, was considered to exhibit anti-inflammatory and antioxidant properties. Our study aimed to investigate the effect of diosmetin in a murine model of cerulein-induced acute pancreatitis (AP). Experimental AP was induced in mice by seven intraperitoneal injecti...

This article provides a review of the current literature on principles symptomatic treatment lymphovenous insufficiency. Lymphovenous insufficiency is an urgent problem modern phlebology, prevalence this pathology reaches 50% among world population. Underlying pathogenesis venous hypertension, which caused by valve insufficiency, outflow obstruction, or combined causes. The use compression knit...