Cough is a natural response from the respiratory tract by increasing clearance of secretions and particles mucus, irritants, foreign particles, microbes, so that it can act as body defense. One way be done to relieve cough symptoms use symptomatic drugs. Diphenhydramine HCl an antihistamine belongs first generation H1 receptor antagonist (H1 blocker) group which has sedative anti-allergic prope...

Diphenhydramine toxicity commonly manifests with antimuscarinic features, including dry mucous membranes, tachycardia, urinary retention, mydriasis, tachycardia, and encephalopathy. Severe toxicity can include seizures and intraventricular conduction delay. We present here a case of a 23-year-old male presenting with recurrent seizures, hypotension and wide complex tachycardia who had worsening...

In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of hist...

Abstract Introduction Accurate assessment of hypersomnia depends upon consideration several factors, including use medications that affect alertness and sleep organization. Urine drug screens (UDS) are recommended when assessing hypersomnia, but there is little standardization with respect to screening methods, types substances detected, in maintenance wakefulness test (MWT) interpretation, par...

Seldom considered to be a drug that causes renal problems, diphenhydramine can have adverse effects in some patients, as illustrated by a case study of a middle-aged veteran. Extra precautions are urged before this medication is prescribed, especially in elderly patients.

There is increasing evidence that a proton-coupled organic cation (H+/OC) antiporter facilitates uptake of various central nervous system-active drugs, such as the histamine H1 receptor antagonist diphenhydramine, into brain. The purpose this study was to clarify structural requirements for H+/OC antiporter-mediated hCMEC/D3 cells, an established in vitro model human blood-brain barrier, by usi...

Parched and ground whole garden slugs are claimed in rural Jamaican folklore practices to have useful effects in the treatment of bronchial asthma. Since this claim may be associated with respiratory dysfunction due to histamine from allergic sensitization, the authors investigated the effects of a semi-pure alcoholic extract (AST-1) on histamine-induced contraction of the guinea pig in vitro t...