BACKGROUND AND OBJECTIVE Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory disease. It is difficult to differentiate between primary and secondary HLH based on clinical findings at the onset of disease. We aimed to find parameters that can help to differentiate primary and secondary HLH at initial diagnosis especially for physicians working in developing countrie...

1992 CLINICAL CHEMISTRY, Vol. 28, No. 9, 1982 data were collected before their communication appeared, the plan of data collection was not influenced by their hypothesis of systematic biases affecting the last two samples of the SMAC batch. Our choice of locations for control samples within the batch was in part determined by the possibility that control results might be influenced by carryover...

EXTENDED ABSTRACT A significant increase in pesticide use has increased concerns about potentially adverse effects on human health and the environment. The study aimed to explore the effects of exposure to pesticides on the liver function and acetycholinesterase levels in serum (AChES) and red blood cells (AChER) of 100 male participating in agricultural work ranging in age between 20 and 60 ye...

It appears that bilirubin IXᾰ has unique structural properties which might have been predicted on the basis of modern concepts of organic chemistry but whose biological implications certainly were not fully appreciated [1]. The initial breakdown product of haemoglobin is UCB (unconjegated or indirect bilirubin) which is insoluble in water but soluble in lipids. This process is catalyzed by an i...

Neonatal Hyperbilirubinaemia is a common finding during the first postnatal week. Physiological jaundice occurs in first week of life in 60% of term and 80% of premature neonates. Non physiologic or pathologic jaundice occurs in 5-10% of newborns which require intervention. According to AAP guidelines laboratory investigation for jaundice include total serum bilirubin, blood Type and coombs tes...

We prepared human conjugated bilirubin by isolation from fresh gall bladder bile and by biosynthesis using liver homogenates. The isolation protocol was modified after Lucassen (doctoral thesis, Univ. Utrecht, 1961), and the in vitro synthesis was done with fresh liver homogenates in the presence of D-glucaro-1,4-lactone (a glucuronidase inhibitor). From direct analyses of these preparations wi...

1. An 18-year-old male college freshman is referred to a gastroenterologist for evaluation of painless jaundice. He initially presented to a campus health center for evaluation of a flu-like illness with high fevers, where mild scleral icterus was noted. Initial laboratory studies revealed a normal complete blood count, normal alkaline phosphatase level, and normal alanine aminotransferase (ALT...

BACKGROUND Several studies have demonstrated that higher serum bilirubin inhibits the inflammation and proliferation of vascular smooth muscle cells; also there is a relationship between serum bilirubin and cardiovascular disease. However, the relationship between bilirubin and atrial fibrillation (AF) is still unknown. In our study, we compared serum bilirubin, between nonvalvular AF patients ...

Background: The purpose of this study was to determine the prevalence of G6PD deficiency in infants with jaundice in Khalij-Fars Hospital of Bandar Abbas in 2015. Methods: In this descriptive-analytic cross-sectional study, which is done in 2015 in Khalij-Fars Hospital of Bandar-Abbas, 226 infants with jaundice were entered. Admission age, hospitalization time, gender, age of birth, birth weig...

Hiperbilirubinemia merupakan peningkatan kadar bilirubin pada bayi baru lahir, terutama minggu pertama kehidupan. banyak terjadi berat lahir < 2500 gram atau yang dari ibu dengan usia kehamilan kurang 37 minggu. Penanganan hiperbilirubinemia menggunakan beberapa terapi standar yaitu foto terapi, transfusi tukar kombinasi dan tukar. Pijatan diberikan dapat meningkatkan fungsi pencernaan melal...