Visceral leishmaniasis (VL) is a severe and often fatal form of caused by Leishmania donovani in the Indian sub-continent. Post Kala-azar Dermal Leishmaniasis (PKDL) late cutaneous manifestation VL, typically occurring after apparent cure but sometimes even without prior history VL India. PKDL serves as significant yet neglected reservoir infection plays crucial role transmission disease, posin...

WHO is honored to cosponsor this important event together with the Ministry of Health of Brazil, ILA and ILEP. We are especially grateful to Government of Brazil and members of the Organizing Committee for planning and organizing the Congress. This is the second important meeting which the Brazilian authorities have kindly hosted this year the first being the meeting of the Global Alliance for ...

In addition to amyloid-b plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered a key feature of Alzheimer’s disease pathology. Inflammation in Alzheimer’s disease is characterized by the presence of reactive astrocytes and activated microglia surrounding amyloid plaques, implicating their role in disease pathogenesis. Microglia in the healthy adult mouse depend on co...

In addition to amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered a key feature of Alzheimer's disease pathology. Inflammation in Alzheimer's disease is characterized by the presence of reactive astrocytes and activated microglia surrounding amyloid plaques, implicating their role in disease pathogenesis. Microglia in the healthy adult mouse depend on co...

14" Methods to mitigate the impacts of emerging infectious diseases affecting wildlife are 15" urgently needed to combat loss of biodiversity. However, the successful mitigation of wildlife 16" pathogens in situ has rarely occurred. Indeed, most strategies for combating wildlife diseases 17" remain theoretical, despite the wealth of information available for combating infections in 18" livestoc...

MHC/self peptide interactions with cognate coreceptor/TCR complexes are central to homeostasis of the T cell repertoire. Recent reports have also underlined the critical role of IL-15/IL-2 cytokines in regulating this homeostatic process. In this study, we investigate mechanisms that regulate potentially autoreactive CD8 cells that have escaped intrathymic selection. These cells, upon exit from...

Methods to mitigate the impacts of emerging infectious diseases affecting wildlife are urgently needed to combat loss of biodiversity. However, the successful mitigation of wildlife pathogens in situ has rarely occurred. Indeed, most strategies for combating wildlife diseases remain theoretical, despite the wealth of information available for combating infections in livestock and crops. Here, w...