BACKGROUND The landscape of Human Immunodeficiency Virus (HIV) research has changed drastically over the past three decades. With the remarkable success of antiretroviral treatment (ART) in decreasing AIDS-related mortality, some researchers have shifted their HIV research focus from treatment to cure research. The HIV cure research community often uses the term eradication to describe the scie...

BACKGROUND AND STUDY AIMS It has been postulated that the endoscopic ablation of Barrett's esophagus can lead to complete eradication of the disease. This study was undertaken to evaluate the efficacy of endoscopic eradication therapy for Barrett's esophagus and the rates of recurrence of intestinal metaplasia. PATIENTS AND METHODS As part of an initial randomized controlled trial, patients w...

Although there have been recent advances with targeted therapies in chronic lymphocytic leukemia (CLL), chemoimmunotherapy remains the treatment of choice; however, this approach is not curative. A key feature of CLL is that it induces a state of immunosuppression, causing increased susceptibility to infections and failure of an antitumor immune response, often worsened by the immunosuppressive...

Through accounts of earlier eradication campaigns as well as speculation on what lies ahead, the authors explore the central question of how the global commu-Global Disease Eradication: nity enters into a commitment to disease eradication. of the previous and current eradication programs have Washington, D.C.: ASM Press (2003) hinged largely on the efforts of one individual who be-196 pp. $39.9...

background: cytomegalovirus (cmv), a problematic virus in solid organ transplant recipients (sotr) such as liver, can worsen overall mortality and transplant outcome, so its prevention and treatment is a key of success in such patients. this study is aimed to compare the efficacy of ganciclovir (gcv) and valganciclovir (vgc) for prevention and treatment of infection with cmv. materials and meth...

background the prevalence of peptic ulcer disease in hemodialysis patients is more than the general population. they are also more prone to complications including upper gastrointestinal bleeding. the aim of this study was to compare the efficacy of 14 days hybrid regimen with 14 days triple therapy for helicobacter pylori ( h . pylori ) eradication in hemodialysis patients. methods forty hemod...

India celebrated its victory over polio on 11th February 2014 after an extraordinary fight against the disease for almost two decades since the introduction of the Global Polio Eradication Initiative (GPEI) in India. The South-East Asia Region of the World Health Organisation (WHO) was certified polio free, on March 27, 2014 by the WHO’s Regional Certification Commission for polio eradication c...

We report on a pilot study for a randomized control trial of pragmatic eradication of Helicobacter Pylori in primary care. Although the sample size is small, pragmatic eradication is likely to be cost-effective for patients with documented or suspected peptic ulcer disease on maintenance acid suppression therapy in primary care.

The ultimate goal of the global programme against lymphatic filariasis is eradication through irrevocable cessation of transmission using 4 to 6 years of annual single dose mass drug administration. The costs of eradication, managerial impediments to executing national control programmes, and scientific uncertainty about transmission endpoints, are challenges to the success of this effort, espe...

Abstract Cocoa Swollen Shoot Virus Disease (CSSVD) has been of great threat to the Ghanaian cocoa industry since 1936. Eradication by cutting out and replanting affected farms main method controlling disease in Ghana. Also, considerable research efforts have yielded several recommendations that farmers are expected implement limit spread disease. However, keeps spreading new areas at an increas...