BACKGROUND Nocturnal desaturation may contribute to long-term pulmonary vascular stress in interstitial lung disease (ILD). We study the prevalence, severity and prognostic utility of nocturnal desaturation across ILD. METHODS ILD patients with overnight oximetry (June 2006-August 2008) were reviewed (n = 134). Significant nocturnal desaturation was considered as > 10% of sleep with SpO2 < 90...

In order to handle complex face image variations in face recognition, multi-image face recognition has been proposed, instead of using a single still-imagebased approach. In many practical scenarios, multiple images can be easily obtained in enrollment and query stages, for example, using video. By accessing these images, a good ”quality” image(s) will be used for recognition using conventional...

OBJECTIVE The introduction of effective treatment strategies in the past two decades has changed the management of RA dramatically. The objective was to analyse the changes in disease activity, function, joint damage and incidence of orthopaedic surgery over a period of 20 years (1989-2009) for patients with RA. METHODS Data acquired from 1989 to 2008 inclusive from the Nijmegen RA inception ...

OBJECTIVES To evaluate the effect of baricitinib on patient-reported outcomes (PROs) in patients with active rheumatoid arthritis (RA) and an inadequate response or intolerance to conventional synthetic disease-modifying antirheumatic drugs. METHODS In this phase III study, patients were randomised 1:1:1 to placebo (N=228), baricitinib 2 mg once daily (QD, N=229) or baricitinib 4 mg QD (N=227...

OBJECTIVE Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). We aimed to detect subtle changes in the circulating lipid profile by shotgun lipidomics analyses and to associate them with four different insulin sensitivity indices. METHODS The cross-sectional study comprised 90 men with a broad range of insulin ...

Transport theory's equation of transfer is a well-accepted model for wave scattering in a random medium. However, exact solutions are only available for a small class of special cases (isotropic scattering in in nite and semiin nite domains) and thus, analytic solutions for a wide variety of geometries and range of parameters which correspond to more physically relevant situations still remain ...

• Metodi statistici per lo studio della distribuzione spaziale del rischio di malattia (disease mapping) • Metodi statistici per la stima del rischio di malattia in presenza di potenziali sorgenti di inquinamento 1

This paper extends the diffusion index (DI) forecast approach of Stock and Watson (1998, 2002) to the case of possibly nonlinear dynamic factor models. When the number of series is large, a two-step procedure based on the method of principal components is useful since it allows the wide variety of the nonlinearity in the factors. The factors extracted from a large Japanese data suggest some evi...

Optimal atrioventricular (AV) delay (AVD) is important for AV sequential pacing. To verify whether optimal AVD can be determined using only Doppler index (DI), adult mongrel dogs with complete AV block were examined with pulsed Doppler echocardiography and hemodynamics measured by a cardiac catheter. After passive-fixation pacing leads were inserted into the right atrium and ventricle, complete...