BACKGROUND Colorectal cancer metastasis is a multistep process involving degradation of extracellular matrix components by proteolytic enzymes. Among them, matrix metalloproteinases (MMPs) are the principal degrading enzymes and their expressions/activities are also correlated with survival. Much research has showed the associations between genetic polymorphisms in MMPs and risk of colorectal c...

To access possible relationships between breast cancer subtypes (BCS) and patterns of distant metastasis in advanced breast cancer. Breast cancer patients with distant metastasis at two academic centers from 2000-2015 were retrospectively reviewed. The breast cancer was classified into four subtypes: hormone receptor (HR) +/ human epidermal growth factor receptor 2 (HER2) - (i.e., estrogen rece...

Lymph node (LN) metastasis is commonly associated with systemic distant organ metastasis in human breast cancer and is an important prognostic predictor for survival of breast cancer patients. However, whether tumor-draining LNs (TDLNs) play a significant role in modulating the malignancy of cancer cells for distant metastasis remains controversial. Using a syngeneic mouse mammary tumor model, ...

PURPOSE To investigate the distribution of Ki67+ cells in breast cancer in relation to clinical-pathological parameters and prognosis. MATERIALS AND METHODS Ki67 expression status was detected in 1,086 breast cancer specimens using immunohistochemistry staining and examining the relationship between the Ki67+ cells' location. Subsequently, clinical-pathological parameters and prognosis were d...

We explored the prognostic significance of the pre-operative-to-post-operative serum carcinoembryonic antigen (pre-post-CEA) ratio in colorectal cancer (CRC). We detected pre- and post-operative CEA levels in 2035 CRC patients surgically treated at First Affiliated Hospital of Zhengzhou University between June 2001 and June 2011. Univariate analysis revealed the pre-post-CEA ratio is associated...

BACKGROUND Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. METHODS In an investigation of 313 women with breast c...

BACKGROUND The aim of this study was to investigate the relationship between positive lymph node ratio (PLNR) and postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS 167 ESCC patients with regional lymph node metastasis, who underwent radical esophagectomy and lymphadenectomy at the Ningbo Yinzhou People's Hospital between October ...

Background: To investigate the value of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) in diagnosing local tumor invasion (T stage), evaluating regional lymph node involvement (N and detecting distant metastasis (M stage) breast cancer patients.

breast conservation surgery combined with radiation therapy is now an accepted option for the treatment of early breast cancer. so we decided to evaluate the results of such treatment in our first group of patients treated by this method. from 1992 to 1996 , one hundred patients with stage i and ii breast cancer treated with breast conservative surgery (lumpectomy or quadrantectomy). were irrad...

background: lung cancer ranks among the most common and most lethal malignancies worldwide. once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. bone, liver, adrenals, and brain are the most frequent sites of the distant disease. in this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa.case presentation...