The possible protective effect of Piper aduncum capsule on DMBA (dimethylbenz[α]anthracene)-induced breast cancer in rats was assessed by monitoring the tumor and lung metastases incidence and recording hematological and biochemical parameters and frequency of micronuclei. Mammary carcinogenesis was induced in 36 female Holtzman rats by providing a single subcutaneous injection of DMBA. Oral ad...

The multiplication of monolayer cultures of transformed rodent cells and normal or transformed human cells was not inhibited by concentrations of 7,12-dimethyIbenz(a)anthracene (DMBA) 200-500 times greater than those that inhibited the multiplication of normal embryonic rodent cells. Fluorescence microscopy showed that DMBA localized to about the same degree within the cytoplasm of cells that w...

Risk factors, such as parental smoking, are commonly associated with increased asthma symptoms and hospitalizations of children. Deseret Mutual Benefits Administrators (DMBA) is the health insurer for employees of The Church of Jesus Christ of Latter-day Saints and their families. Due to religious proscription, employees abstain from alcohol and tobacco use, creating a cohort of children not ex...

The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30 mg kg(-1) b.w.). Pretreatment of ferulic acid orally a...

The tumor-producing effect of dibenz(a,h)anthracene led Cook (5) to undertake experiments showing that 9-isopropyl BA is a (weak) carcinogenand Fieseret aL (9) synthesized the stronger cancer-producing substances 7-methyl-BA and 7,8-DMBA. Considerably later it was found that 7,12-DMBA (1), 7,8,12-TMBA (1), and 6,7,8-TMBA (21) are very powerful carcinogens. It was evident that substitution of BA...

Ung thư vú là loại ung phổ biến nhất ở phụ nữ. Gần đây, bên cạnh các phương pháp điều trị cổ điển, dược liệu và y học truyền đang trở nên ngày càng trong hỗ trợ ngăn ngừa thư. Nghiên cứu này nhằm đánh giá tác động của cao chiết từ vỏ quả măng cụt (Garcinia mangostana L.) trên mô hình bệnh do 7,12-dimethylbenzeneanthracene (DMBA) chuột nhắt cái. Chuột cái chủng Swiss, trưởng thành được cho uống ...

Objectives: The primary objective of this study was to assess the pharmacological activity Cinnamaldehyde (CA) obtained from cinnamon bark in 7, 12-Dimethylbenz antharacene (DMBA)-induced skin cancer albino mice and important cell antioxidant enzymes levels which play an role cancer. Methods: Cinnamon collected obtain CA phytochemical screening extract performed. Then done with cancer, after 12...

background: animal suitable models are very useful tools in the studies of complicated diseases. in this way we can study the heterogeneity of human genome and also we can minimize the effect of environmental factors in the incidence of cancers. in this study the expression of vwf and pcna in tumors was determined by immunohistochemistry and also we measured three cancer markers and two blood f...

Haloalkane dehalogenases are enzymes that catalyze the cleavage of the carbon-halogen bond by a hydrolytic mechanism. Genomes of Mycobacterium tuberculosis and M. bovis contain at least two open reading frames coding for the polypeptides showing a high sequence similarity with biochemically characterized haloalkane dehalogenases. We describe here the cloning of the haloalkane dehalogenase genes...

We have previously reported that 7,12-dimethylbenz(a)an thracene (DMBA), given i.v. 24 hr after partial hepatectomy when DNA replication is maximal, binds tightly to DNA, inhibits its synthesis, and induces neoplastic changes in regenerating rat liver. We now report that DMBA injected i.v. 5 hr after partial hepatectomy (i.e., during the early prereplicative phase) inhibits DNA synthesis for at...