نتایج جستجو برای: dmpc cpg odn nanoliposomes

تعداد نتایج: 15489  

2016
Xiao-Rui Liu Yu-Na Guo Chuan-Mei Qin Xiao-Li Qin Fei Tao Fei Su Fu-Ju Tian Yan Zhang Yi Lin

Intrauterine infection is one of the most frequent causes of miscarriage. CpG oligodeoxynucleotide (CpG ODN) can mimic intrauterine infection. CpG ODN-induced embryo-resorption was observed consistently in the NK-cell deficient non-obese diabetic (NOD) mice but not in the wild-type (WT) mice. To elucidate the molecular mechanisms of differential pregnancy outcomes, differentially expressed gene...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Ken J Ishii Koji Kawakami Ihsan Gursel Jacqueline Conover Bharat H Joshi Dennis M Klinman Raj K Puri

Despite urgent need, no single strategy has been widely effective at controlling the growth of rapidly progressive solid tumors. We demonstrate here a potent antitumor therapy using modified bacterial DNA and toxin. Treatment of human head and neck cancer established as xenografts in athymic mice with immunostimulatory CpG oligodeoxynucleotides encapsulated in sterically stabilized cationic lip...

2012
Jing-Yiing Wu Cheng-Chin Kuo

Nucleic acid cellular uptake into endosomes is critical in eliciting nucleotide-sensing toll-like receptors (TLRs) innate immune responses. ADP-ribosylation factor 6 (ARF6) is a member of the Ras superfamily, which is critical to a wide variety of cellular events including endocytosis. Our previous report indicated that ARF6 plays a critical role in CpG ODN/TLR9-mediated responses. Here, we fur...

Journal: :Infection and immunity 2001
R A Gramzinski D L Doolan M Sedegah H L Davis A M Krieg S L Hoffman

Unmethylated CpG dinucleotides in bacterial DNA or synthetic oligodeoxynucleotides (ODNs) cause B-cell proliferation and immunoglobulin secretion, monocyte cytokine secretion, and activation of natural killer (NK) cell lytic activity and gamma interferon (IFN-gamma) secretion in vivo and in vitro. The potent Th1-like immune activation by CpG ODNs suggests a possible utility for enhancing innate...

Journal: :Infection and immunity 2004
Surasakdi Wongratanacheewin Wannapa Kespichayawattana Pakamas Intachote Sathit Pichyangkul Rasana W Sermswan Arthur M Krieg Stitaya Sirisinha

Although CpG oligodeoxynucleotides (CpG ODNs) are known to enhance resistance against infection in a number of animal models, little is known about the CpG-induced protection against acute fatal sepsis such as that associated with the highly virulent bacterium Burkholderia pseudomallei. We previously demonstrated in an in vitro study that immunostimulatory CpG ODN 1826 enhances phagocytosis of ...

Journal: :Developmental and comparative immunology 2012
Haiqi He Kenneth J Genovese Christina L Swaggerty Kathryn M MacKinnon Michael H Kogut

Toll-like receptors (TLRs) are pattern recognition receptors of the innate immune system for various conserved pathogen-associated molecular motifs. Chicken TLR3 and TLR21 (avian equivalent to mammalian TLR9) recognize poly I:C (double-stranded RNA) and CpG-ODN (a CpG-motif containing oligodeoxydinucleotide), respectively. Interaction between TLR3 and TLR21 agonists poly I:C and CpG-ODN has bee...

Journal: :International journal of oncology 2010
Milan Reinis Ivan Stepanek Jana Simova Jana Bieblova Hana Pribylova Marie Indrova Jan Bubenik

Downregulation of MHC class I expression on the cell surface is a common mechanism by which tumour cells, including cervical carcinoma, can escape the T cell-mediated anti-tumour immunity. This downregulation represents an obstacle for the efficacy of anti-tumour vaccines. In this study, we investigated the efficacy of prophylactic peptide and peptide-pulsed dendritic cell-based vaccines in a m...

2012
Michele Sommariva Loris De Cecco Elda Tagliabue Andrea Balsari

We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.

Journal: :The Journal of infectious diseases 2006
Mathieu Barrier Sonia Lacroix-Lamandé Roselyne Mancassola Gaël Auray Nelly Bernardet Anne-Marie Chaussé Satoshi Uematsu Shizuo Akira Fabrice Laurent

BACKGROUND Neonates are particularly vulnerable to infections, in part because of the incomplete development of their immune system. Recent advances in immunostimulatory treatments based on conserved microbial components led us to assess the potential of oligodeoxynucleotides (ODNs) for decreasing the sensitivity of neonates to Cryptosporidium parvum infection. METHODS Neonate mice were treat...

Journal: :Journal of immunology 2002
Klaus Heckelsmiller Katharina Rall Sebastian Beck Angelika Schlamp Julia Seiderer Bernd Jahrsdörfer Anne Krug Simon Rothenfusser Stefan Endres Gunther Hartmann

The immune system of vertebrates is able to detect bacterial DNA based on the presence of unmethylated CpG motifs. We examined the therapeutic potential of oligodeoxynucleotides with CpG motifs (CpG ODN) in a colon carcinoma model in BALB/c mice. Tumors were induced by s.c. injection of syngeneic C26 cells or Renca kidney cancer cells as a control. Injection of CpG ODN alone or in combination w...

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