نتایج جستجو برای: dna binding proteins

تعداد نتایج: 1239590  

Journal: :Science 2009
Gwenael Badis Michael F Berger Anthony A Philippakis Shaheynoor Talukder Andrew R Gehrke Savina A Jaeger Esther T Chan Genita Metzler Anastasia Vedenko Xiaoyu Chen Hanna Kuznetsov Chi-Fong Wang David Coburn Daniel E Newburger Quaid Morris Timothy R Hughes Martha L Bulyk

Sequence preferences of DNA binding proteins are a primary mechanism by which cells interpret the genome. Despite the central importance of these proteins in physiology, development, and evolution, comprehensive DNA binding specificities have been determined experimentally for only a few proteins. Here, we used microarrays containing all 10-base pair sequences to examine the binding specificiti...

Clostridium Botulinum Type E neurotoxin heavy chain consists of two domains: the translocation domain asthe N-terminal half and the binding domain as the Cterminal half (Hc). One effective way to neutralize botulinum neurotoxin is to inhibit binding of this toxin to neuromuscular synapses with antibodies against binding domain. Two synthetic genes, coding for Hc (the full length binding d...

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