Small molecules that interact with DNA, disrupting the binding of transcription factors or crosslinking DNA into larger structures, have significant potential as cancer therapies and in nanotechnology. Bisintercalators, including natural products such as echinomycin and rationally designed molecules such as the bis-9-aminoacridine-4-carboxamides, are key examples. There is little knowledge of t...

With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple has been utilized to attain such constructs. However, it needs many talented pre...

A construction method for duplex cage structures with icosahedral symmetry made out of single-stranded DNA molecules is presented and applied to an icosidodecahedral cage. It is shown via a mixture of analytic and computer techniques that there exist realisations of this graph in terms of two circular DNA molecules. These blueprints for the organisation of a cage structure with a noncrystallogr...

Quantifying the basic intra- and inter-molecular forces of DNA has helped us to better understand and further predict the behavior of DNA. Single molecule technique elucidates the mechanics of DNA under applied external forces, sometimes under extreme forces. On the other hand, ensemble studies of DNA molecular force allow us to extend our understanding of DNA molecules under other forces such ...

DNA nanostructures and aptamers are both promising tools in numerous fields, particular biology medicine, thanks to their respective advantages. In recent years, there has been a growing trend of integrating these two emerging with much progress having achieved. The convergence nucleic acid aptamer nanotechnology led many powerful nanoplatforms for biosensing, bioimaging, targeted drug delivery...

Nanoparticles tethered with DNA strands are promising building blocks for bottom-up nanotechnology, and a theoretical understanding is important for future development. Here we build on approaches developed in polymer physics to provide theoretical descriptions for the equilibrium clustering and dynamics, as well as the self-assembly kinetics of DNA-linked nanoparticles. Striking agreement is o...

Abstract Over the past 40 years, significant progress has been made on design and implementation of nucleic acid circuits, which represent computational core dynamic DNA nanotechnology. This enabled primarily by substantial advances in experimental techniques, but also parallel methods for circuit design. In this perspective, we look back at evolution these through lens Visual DSD system, devel...