background: oleuropein is a phenolic compound which is present in the olive leaf extract. the purpose of the present study was to investigate the neuroprotective effect of oleuropein as an antioxidant agent on the substantia nigra in aged rats. methods: twenty 18-month-old wistar rats (450-550 g) were randomly divided into control and experimental groups. the experimental group received a daily...

background and objective: parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. in recent years, there have been interests in the role of the free radical damage in pd. cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. this research focused on the effects of cinnamon extract and cinn...

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

Dopamine constitutes about 80% of the content of central catecholamines and has a crucial role in the etiology of several neuropsychiatric disorders, including Parkinson's disease, depression and schizophrenia. Several dopaminergic drugs are used to treat these pathologies, but many problems are attributed to these therapies. Within this context, the search for new more efficient dopaminergic a...

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by rigidity, resting tremor, and bradykinesia. It is produced by the selective loss of dopaminergic neurons within the substantia nigra pars compacta (SN). PD affects millions people worldwide being the second most common age-related neurodegenerative disorder with a prevalence of 1900 per 100,000 in people over ...

Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...

Opioids modulate brain dopaminergic function in various experimental paradigms. This study used the rotational model of behavior in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway to investigate this interaction. Doses of two presynaptically acting dopaminergic drugs, amphetamine and cocaine, were coadministered with several doses of the mu opioid agonist, mo...

OBJECTIVES To investigate decision making in patients with primary restless legs syndrome (RLS) with and without augmentation treated with dopaminergic medication. METHODS A total of 64 non-demented RLS patients treated with dopaminergic medication with and without augmentation were included in this study. We used an information sampling task to assess how much evidence participants gather be...

UNLABELLED In this report, we describe a female patient with both prolactinoma and psychotic disorder who was successfully treated with aripiprazole, a partial dopamine 2 receptor agonist. During the follow-up of more than 10 years, her psychotic symptoms improved considerably, prolactin levels normalised and the size of the prolactinoma decreased. This observation may be of clinical relevance ...

Introduction Orthostatic hypotension is a relatively common symptom caused by a variety of aetiologies. The most common of these are: neuropathies due to systemic diseases such as diabetes, amyloidosis and porphyria; vaso-vagal attacks; hypovolaemia; ShyDrager syndrome (idiopathic orthostatic hypotension); adverse effects of anti-adrenergic drugs, L-dopa and dopaminergic drugs; phaeochromocytom...