WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT The phosphodiesterase (PDE) type 5 inhibitor is a widely used agent that facilitates penile erection. Udenafil is newly developed as a PDE-5 inhibitor. WHAT THIS STUDY ADDS This is the first study to determine the safety, tolerability and pharmacokinetics of udenafil in healthy subjects. Udenafil was safe and well tolerated in healthy Korean subjects. ...

The ability of the clinically used cephalosporins: cephalothin, cefotaxime and cefotiam to induce lipid peroxidation (LPO) and renal damage was compared to that of nephrotoxic cephaloridine under in vivo conditions. Glutathione was measured in rat liver or in renal cortex as non-protein sulfhydryls. LPO was measured in plasma, renal cortex and liver by the generation of malondialdehyde or as th...

BACKGROUND Our goals were to describe azithromycin (AZI) pharmacokinetics in maternal plasma (MP), fetal plasma (FP), and amniotic fluid (AF) following intra-amniotic infection (IAI) with Ureaplasma in pregnant rhesus monkeys and to explore concentration-response relationships. METHODS Following intra-amniotic inoculation of Ureaplasma parvum, rhesus monkeys received AZI (12.5 mg/kg every 12 ...

Ion bombardment provides an opportunity to study basic properties of intrinsic defects in materials since the radiation-induced disorder accumulation depends on balance between defect generation and migration rates. In particular, variation such parameters as irradiation temperature ion flux, known literature dose-rate effect, interconnects macroscopically measured lattice with barrier dominati...

Even using an authenticated synchronous broadcast model, the task of unforgeably time-stamping digital documents still presents some problems. It is simply not practical to assume that all participants will record and store everyone else's documents so that creation times can be veri ed. This paper presents a time and space e cient method for accumulation of time-stamped documents. Whenever a q...

Papers published in this report series are preliminary versions of journal articles and not for quotations. Abstract This paper extends the real options literature by discussing an investment problem, where a firm has to determine optimal investment timing and optimal capacity choice at the same time under conditions of irreversible investment expenditures and uncertainty in future demand. Afte...

............................................................................................................................. ii Dedication ......................................................................................................................... iii Acknowledgments ............................................................................................................ iv Tab...

Molecular dynamics simulations of microstructural evolution under irradiation (U,Pu)O2 solid solutions have been carried out with the Frenkel pair accumulation method two empirical potentials. Simulated X-Ray diffraction patterns systematically generated along pathway from computed atomistic configurations. Description for each these well characterized damage microstructure snapshots is discuss...