In clinical trials response variables are measured at different times and doses. This paper explores methods to determine the dose that optimizes the response based on multiple responses and doses. Linear dose-response modeling can be performed using repeated measures analysis (using PROC MIXED) for change in response (Y) using dose (X) as a continuous explanatory variable with time, dose, and ...

Simulations of intense laser-solid interactions reveal the optimal configuration laser intensity and duration at constant energy to maximize 1--5 MeV x-ray yield. A phenomenological model predicts hot-electron temperature as a function parameters density scale length.