A double blind trial of opipramol (Insidon) compared with placebo for a group of matched patients suffering from migraine has been carried out. The total number of the migraine attacks in a group of 14 patients on opipramol (as compared with the same patients during a pretreatment period of six weeks) showed a 33% reduction in the number of attacks experienced during the first six weeks. During...

Designs of the double sampling (DS) X chart are traditionally based on the average run length (ARL) criterion. However, the shape of the run length distribution changes with the process mean shifts, ranging from highly skewed when the process is in-control to almost symmetric when the mean shift is large. Therefore, we show that the ARL is a complicated performance measure and that the median r...

Rachel Kneen should be listed as the fifteenth author. Her affiliations are 1: Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom, and 8: Alder Hey Children’s National Health Service Foundation Trust, Liverpool, United Kingdom. The author contributions of this author are as follows: conceived and designed the experiments, performed the experiments, anal...

Acetaminophen has recently been recognized as having impacts that extend into the affective domain. In particular, double blind placebo controlled trials have revealed that acetaminophen reduces the magnitude of reactivity to social rejection, frustration, dissonance and to both negatively and positively valenced attitude objects. Given this diversity of consequences, it has been proposed that ...

Treatment with Anti-Tumor Necrosis Factor (anti-TNF) therapy has become a mainstay of therapy for patients with CD who are unresponsive to conventional medical management. Currently there are three anti-TNFα antibodies that have been approved by the US Food and Drug Administration for the treatment of CD, namely infliximab, adalimumab and certolizumab pegol (CZP). Several double blind placebo c...

The efficacy of ranitidine was evaluated using a two-staged trial in patients with endoscopically moderate or severe reflux oesophagitis. The results of a six week double blind placebo controlled trial (stage I) in 36 patients shows that ranitidine (150 mg bd) is superior to placebo in the acute treatment with significant symptomatic improvement concerning heartburn and regurgitation, and in he...

Fifty cases of 1epromatous leprosy we re inc Juded in a double blind trial to assess the therapeutic value of D A D D S in lepromatous lepros y using DDS as the control drug. During the period of 1 9 months the study has been in progress, 2 8 cases were lost to the study owing to patients going away on voluntar y d ischarge , etc. In the 2 2 cases who continued to participa t e in the study ove...

Bhatia A, Bril V, Brull RT, et al. Study protocol for a pilot, randomised, doubleblinded, placebo controlled trial of perineural local anaesthetics and steroids for chronic posttraumatic neuropathic pain in the ankle and foot: the PREPLANS study. BMJ Open 2016;6:e012293. The first name of the sixth author was misspelled; the correct spelling is Sabeeh. In the Contributors section this author’s ...

The steroid sparing effect of nebulised budesonide suspension was assessed in a double blind placebo controlled parallel group study of 36 preschool children with severe asthma who were dependent on treatment with oral steroids. Nebulised budesonide suspension significantly reduced the requirement for treatment with oral steroids, and produced a marked improvement in overall health as scored on...

OBJECTIVE Investigate whether the gut feelings of one person, as measured with an electrogastrogram (EGG), respond to the emotions of a distant person. DESIGN In a double blind protocol, EGG activity was recorded in an individual relaxing in a heavily shielded chamber while, at a distance, a second person periodically viewed the live video image of the first person along with stimuli designed...