sepsis is a systemic inflammatory response to infection. sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. pathogenesis is extremely complex. in recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. sepsis damages the structure and function of mitochondria,conversely, mito...

background: multi drug resistant (mdr) pseudomonas and acinetobacter species are defined as resistant to at least three classes of antibiotics. most studies have demonstrated that mdr gram negative infections convey increased mortality and morbidity. case: an 11-year –old girl was admitted to pediatric burns unit with burn injury of approximately 68% total body surface area (tbsa). discussion: ...

background increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (mtx). the aim of this study, therefore was to evaluate the incidence of mtx induced hepatotoxicity and its risk factors among rheumatoid arthritis (ra) patients. methods this retrospective study described 286 patients with ra who received ≤ 7.5 mg mtx weekly...

introduction: spontaneous perforation of the nasal septum is an uncommon condition. nasal inhalation of substances such as cocaine has long been linked to this perforation. case report: this report describes the case of a 46-year-old woman who was addicted to methamphetamine and who presented with perforation of the nasal septum.this is the first reported case of nasal septal necrosis linked to...

adverse drug reaction (adr) is one of the most life threatening problems, and the economic burden of adr is considerable. the main objective of this study was to assess the attitude of the kerman health system staff, to evaluate their knowledge of the spontaneous reporting system and to identify the reasons for low reporting rate. in this descriptive study, a persian translated questioner was u...

187 commercial checken flocks affected with respiratory diseases were examined for ornithobacterium rhinotracheale isolation. the bacterium was isolated from 105 (56.2%) poultry flocks. drug sensitivity test using standard disk diffusion technique was performed with 19 antibiotics. all the isolates were susceptible to tiamulin and most of them were susceptible to chloramphenicol and linco-spect...

conclusions the results of this study indicated that a decrease in oprd gene expression is an important mechanism of resistance in carbapenem resistant pseudomonas aeruginosa isolated from severe burn patients with secondary infection. results our study showed that 94.2% of the isolates were resistant to imipenem, 99.5% to meropenem, and all were resistant to ertapenem. the oprd gene expression...

conclusions these results indicate that the epidemic of risk behavior varies in subjects according to factors including gender, the university where one studies, parents’ occupation and their income, and the number of family members. results the research indicates that 45.2% of students sometimes, mostly, or always have an improper diet, 56.5% have no physical activity, 62.3% have experienced u...

conclusions there is a need to train health staff, and the community, concerning preventive measures, treatment, and reducing harm for substance drug users. results among 402 idus patients, a large amount of them were male, single, and younger than 39 years. regarding psychotic and somatic symptoms caused by methadone therapy, most of the participants had no problem with methadone maintenance t...