gamma-scintigraphy is applied extensively in the development and evaluation of pharmaceutical delivery systems, particularly for monitoring formulations in the gastrointestinal and respiratory tracts. the radiolabelling is generally achieved by the incorporation of an appropriate radionuclide such as technetium-99m or indium-111 into the formulation or by addition of a non-radioactive isotope s...

The purpose of current article focuses on polymers used in mucoadhesive drug delivery system. The term “mucoadhesive” is defined as the “attachment of drug elongated with asuitable carrier like natural or synthetic polymer to mucus and/or an epithelial surface”. It is a popular novel drug delivery system because relatively permeable of mucous membranes, and mucus have higher blood flow therefor...

BACKGROUND The aim of this pilot study was to evaluate patients' self-reported attitudes towards medication-related factors known to impair adherence and to assess their prevalence in ambulatory care as an essential prerequisite to improve patient adherence. METHODS We conducted a face-to-face interview with 110 primary care patients maintained on at least one drug. For each drug, the patient...

Objective: The present work was undertaken with the aim to develop and validate a rapid and consistent stability indicating RP-HPLC in which the peaks will be appear with short period of time as per ICH Guidelines. The proposed method was simple, fast, accurate and precise method for the Quantification of drug in the dosage form, bulk drug as well as for routine analysis in Quality control. Met...

Polymers are tools used in novel drug delivery system to modify the drug release of pharmaceutical dosage form. Polyox is hydrophilic polymer made of non-ionic homopolymer of ethylene oxide. Polyox is popular for its film forming, binding, lubricating, mucoadhesive, viscosity imparting property in pharmaceuticals. Polyox are available in various grades based on its molecular weight. Lower molec...

Pharmacokinetic studies are an integrated part of the development program of a new drug. They are intended to define the time course of drug and major metabolite concentrations in plasma and other biological fluids in order to obtain information on absorption, distribution, metabolism, and elimination. In preclinical studies, pharmacokinetics (PK) is often used to interpret toxicological result...

Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

Research & Development in Material Science Controlled Drug Release from Loratadine-Loaded Pectin Film Dosage Forms Yoshifumi Murata*, Sae Sugimoto, Chieko Maida and Kyoko Kofuji Faculty of Pharmaceutical Science, Hokuriku University, Japan *Corresponding author: Murata, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Submission: February 21, 2022;Published: 25, 2022 DOI: 10.31031/RDMS.2022.16.000895 I...

Introduction Efficacy and safety of antidepressant drug therapy may be limited by inter-individual differences in concentration. Accounting for this inter-individuality, Therapeutic Drug Monitoring (TDM) enables clinicians to adjust dosage based on individual information concentration attained blood. However, research the basic assumption TDM, association between effect, has yielded ambiguous r...