EDITORIAL article Front. Oncol., 20 July 2023Sec. Pharmacology of Anti-Cancer Drugs Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1248272

The research focuses on the development and optimization of ifosfamide nanostructured lipid carriers for oral delivery with the application of response surface methodology. The objectives of the study were to develop a formulation for ifosfamide to be delivered orally, overcome the instability of the drug in acidic environment during oral administration, to sustain the release, drug leakage dur...

Abstract Targeted delivery of drugs to tumor cells, which circumvent resistance mechanisms and induce cell killing, is a lingering challenge that requires innovative solutions. Here, we provide two bioengineered strategies in nanotechnology blended with cancer medicine preferentially target distinct drug resistance. In the first ‘case study’, demonstrate use lipid–drug conjugates molecular sign...

A Target Animal Safety protocol was used to examine adverse events in male and female Fischer F344/NTac rats treated with increasing doses of a subcutaneous implant of a lipid suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of drug for 3 days. Chemistry, hematology, coagulation, and urinalysis values with 2- to 10-fold excess doses of t...

Lipid-based nanostructures have garnered considerable interests over the last two decades, and achieved tremendous clinical success including first approval of a liposome (Doxil) for cancer therapy in 1995 recent COVID-19 mRNA lipid nanoparticle vaccines. Compared to liposomes which bilayer surrounding an aqueous core, nanoparticles with particle structure several attractive advantages encapsul...