The general approach and initial management of patients with suspected or confirmed poisoning will be reviewed here. Specific issues relating to the management of common drug overdoses are discussed separately (see appropriate topic reviews). A topic devoted to the management of the critically ill patient with an unknown overdose is found separately. (See "Initial management of the critically i...

We present the unique case of severe, symptomatic bradycardia associated with pregabalin overdose. Pregabalin is a widely prescribed drug not routinely sinus bradycardia. A 39 year old male, presented having taken about 4g pregablin intention to self-harm.

OBJECTIVES Non-fatal overdose remains a significant source of morbidity among people who inject drugs (IDU). Although depression and social support are important in shaping the health of IDU, little is known about the relationship between these factors and overdose. Therefore, we sought to determine whether depressive symptoms and social support predicted non-fatal overdose among IDU in a Canad...

BACKGROUND North America is currently experiencing an overdose epidemic due to a significant increase of fentanyl-adulterated opioids and related analogs. Multiple jurisdictions have declared a public health emergency given the increasing number of overdose deaths. In the province of British Columbia (BC) in Canada, people who use drugs and who are unstably housed are disproportionately affecte...

BACKGROUND Naloxone has been evidenced widely as a means of reducing mortality resulting from opiate overdose, yet its distribution to drug users remains limited. However, it is drug users who are most likely to be available to administer naloxone at the scene and who have been shown to be willing and motivated to deliver this intervention. The current study builds on a national training evalua...

The newer antidepressants are as efficacious as the older agents in the treatment of depression. They have a side effect profile that is different from the older drugs and are generally better tolerated. Drug-drug interactions do exist with some of these agents and can usually be predicted from knowledge of their metabolism. When taken in overdose as the sole agents they are rarely fatal; seizu...

poly-drug use refers to the use of two or more substances at the one time or repeatedly. it is common among both recreational and regular drug users across the world. poly-drug use is a great contributor to the global number of deaths related to drug overdose. in this case, the likelihood of drug overdose and its pertaining complications in an individual is higher especially when benzodiazepine...

We describe two recently proposed machine learning approaches for discovering emerging trends in fatal accidental drug overdoses. The Gaussian Process Subset Scan enables early detection of emerging patterns in spatio-temporal data, accounting for both the non-iid nature of the data and the fact that detecting subtle patterns requires integration of information across multiple spatial areas and...

OBJECTIVE To review the diagnosis and management of drug overdose and poisonings in a two-part presentation. DATA SOURCES A review of articles reported on drug overdose and poisonings. SUMMARY OF REVIEW In patients who attempt suicide it is usual for the overdose to be a therapeutic agent, although in the severely mentally disturbed patient the agent may be an unusual poison. As with any ov...