determination of drug resistance rate, as a new major problem in patients with typhoid fever is inevitable for treatment of the disease. in a cross-sectional study, during march 1994 till february 1995, a total of 39 patients with typhoid fever admitted to dept. of infections diseases, emam khomeini hospital, and were examined for the rate of resistance to routine drugs usually used for treatme...

extensively drug-resistant tuberculosis (xdr-tb) is a new challenge for tuberculosis control programs. lack of effective drugs and high rate of failure in treatment and mortality is a major threat for public health. treatment of this serious infection needs well-designed individualized dosage regimen and powerful national tb program. in this review we will describe the xdr-tb definition and its...

OBJECTIVES To evaluate a novel series of quinoxaline 1,4-di-N-oxides for in vitro activity against Mycobacterium tuberculosis and for efficacy in a mouse model of tuberculosis (TB). METHODS Ketone and amide derivatives of quinoxaline 1,4-di-N-oxide were evaluated in in vitro and in vivo tests including: (i) activity against M. tuberculosis resistant to currently used antitubercular drugs incl...

The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

the resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. infection of drug-resistance bacteria seriously threatens human health. currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. in this paper, a series of (s,z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

Some drug management systems have been established in Japanese hospitals to reduce medical cost and regulate drug use. Among the many available prescription drugs, antimicrobials should be used special attention because their indiscriminate use often leads to sudden outbreaks of resistant bacteria. As drug specialists, pharmacists should monitor the use of all drugs, in particular, antimicrobia...

Microbial infections are still among the major public health concerns since several yeasts and fungi, other pathogenic microorganisms, responsible for continuous growth of drug resistance against bacteria. During COVID-19 pandemic outbreak antimicrobial rate is fostering need to develop new strategies drug-resistant superbugs. Thus, a novel technological approach on improving existing drugs gai...

The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...