The aim of this study was to investigate the effect of different carriers on solubility and in vitro dissolution of poorly water soluble drug meloxicam (MLX). Solid dispersions with Polyethylene glycol-6000 (PEG6000), Poloxamer 188 (Plx188), Poloxamer 407 (Plx407) and inclusion complexes (ICs) with β cyclodextrin (β-CD) were prepared by different methods in three different weight ratios. All SD...

In the present work, gliclazide loaded polyethylene glycol (PEG) based solid dispersions were prepared using fusion method in order to improve the solubility and dissolution rate of gliclazide. The compatibility of the drug with various formulation components was established. Solid dispersions (SDs) of gliclazide and polyethylene glycol (PEG 4000, 6000 and 8000) at three mass ratios (1:1, 1:3, ...

Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature in...

Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E...

In the preformulation study physical compatibility of the drug-excipient was screened and compatibility was observed between Zaltoprofen and selected solubilizers. In the drug solubilizers interference study no interference was observed in UV spectrophometric analysis of Zaltoprofen in presence of employed solubilizers. Aqueous solubility of Zaltoprofen was found 0.028 mg/ml. The solubilizers s...

Sildenafil citrate (SC), a drug used to treat erectile dysfunction, is available in tablet form but has three major problems. First, the drug displays inadequate aqueous solubility, which delays the onset of its action. Second, the drug undergoes extensive first-pass metabolism, resulting in a low (40%) bioavailability. Third, the gastrointestinal effects of SC include dyspepsia and a burning s...

Telmisartan is a potent, long-lasting, nonpeptide antagonist of the angiotensin II type-1 (AT1) receptor that is indicated for the treatment of essential hypertension. It selectively inhibits stimulation of the AT1 receptor by angiotensin II without affecting other receptor systems involved in cardiovascular regulation. Very high lipophilicity a unique feature of telmisartan coupled with a high...

INTRODUCTION Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poor aqueous solubility of lipophilic drugs creates problems in formulation as well as in oral administration. Various approaches have been developed to resolve poor aqueous solubility of lipophilic drugs. As oral route for drug administration ...

Etoricoxib is an anti-inflammatory drug largely used in a variety of acute and chronic inflammatory diseases, but is associated with low aqueous solubility and poor dissolution leading to a delayed rate of absorption and onset of action. This study focuses on the development and pharmacological evaluation of a series of binary systems of etoricoxib with cyclodextrins. The binary systems of etor...

During the last two decades, many modern technologies have been established in the pharmaceutical research and development area. The automation of the drug discovery process by technologies such as high-throughput screening, combinatorial chemistry, and computer-aided drug design is leading to a vast number of drug candidates possessing a very good efficacy [1]. Unfortunately, many of these dru...