BACKGROUND The features of acute classical recreational drugs or new psychoactive substances (NPS) toxicity fall into three broad groups: (i) stimulant; (ii) hallucinogenic and (iii) depressant. Currently, there is no information available on healthcare professionals knowledge/confidence in managing the acute toxicity related to NPS use. AIM We have compared knowledge and confidence of managi...

The staggering cost of bringing a drug to market coupled with the extremely high failure rate of prospective compounds in early phase clinical trials due to unexpected human toxicity makes it imperative that more relevant human models be developed to better predict drug toxicity. Drug-induced nephrotoxicity remains especially difficult to predict in both pre-clinical and clinical settings and i...

Abstract Background and Objective: Iranian Traditional Medicine (ITM) has a long history in the prevention and treatment of diseases. Clinical uses, side effects, and toxic effects of many singular and compounds were known to scientists of ITM and articular books on toxicology and detoxification of drugs has been written by scientists, but their measurement tools to evaluate chronic toxicity of...

BACKGROUND Hospital admissions for acute recreational drug toxicity are coded using the International Classification of Diseases (ICD-10) coding system. It is unclear how these admissions are coded, as often there are no specific ICD-10 codes for the drug(s) involved. This study was undertaken to determine how acute recreational drug toxicity admissions are routinely coded. DESIGN Questionnai...

Signs and symptoms of D PH toxicity were seen in an epileptic child who had received DPH and MP concurrently. In the absence of liver and kidney disease and any intercurrent infection, and with the patient's recovery following the withdrawal of DPH, it appears that drug-drug interaction is the most logical explanation for DPH intoxication.

Some formulations of liposomal doxorubicin with intermediate rates of drug release have shown increased levels of toxicity in mice. Because antibody-mediated targeting of liposomal drugs influences the pharmacokinetics, mechanism of uptake, and selectivity of the associated drugs, we hypothesized that anti-CD19-mediated targeting of liposomal doxorubicin might moderate the toxicity of the probl...

Background: Reproductive toxicity studies (RTS) represent an important part of pre-clinical safety evaluation of any drug development process for human consumption. It is mandatory requirement that RTS must be completed before any drug can be administered to women of childbearing age. Therefore, at first segment of toxicity check the toxic effect of the drug on fertility must be tested on non-c...

Introduction: Polymorphisms are the main genetic factors associated with toxicities of antituberculosis drugs. This literature review summarizes polymorphisms genes that code for enzymes metabolism drugs and their transmembrane transporters. Some mechanisms drug-associated strategies management have also been described in this review. Methods: The bibliographic searches were exclusively carried...