Differential renal function assessment using 99mTc-DTPA was carried out in 12 children aged between 3 weeks and 11 years who had undergone surgical procedures which allowed separate access to the urine output from each kidney. The results correlated well with those obtained by measuring individual kidney creatinine clearances. The best result was obtained using the technique of deconvolution an...

introduction: hydronephrosis is one of the major causes of referring infants for nuclear medicine investigation. renal dynamic study is the most reliable investigation for such children. however direct evaluation of renogram leads to generation of parameters that have no physiological interpretation. the configuration of renogram is very much dependent upon the rate at which radiopharmaceutical...

We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are associated with plaques vulnerable to rupture. Therefore, macrophage scavenger rece...

UNLABELLED The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of this study was to investigate the transcriptional, functional, and morphological effects on renal tissue after 177Lu-octreota...

Gadopentetate dimeglumine (gadolinium diethylenetriaminepentaacetic acid [DTPA]) was prospectively administered to 15 consecutive neonates and young infants (less than 6 weeks old) referred for routine cranial magnetic resonance (MR) imaging. The goals of the study were (a) to provide preliminary safety and efficacy data concerning the use of this drug in neonates and (b) to determine whether t...

Objective: An abnormal filtration fraction due to divergence between glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) may lead to different estimations of absolute renal function, depending on the radiopharmaceutical administered. The purpose of this study was to estimate GFR and ERPF by measuring the clearances of technetium-99m diethylenetriamine pentaacetic acid (99mTc...

OBJECTIVE The relationship between stressful life events and multiple sclerosis (MS) exacerbations or radiological disease activity is at best controversial. The aim of this study is to examine the relationship between exposure to war-related events incurred during the July 2006 Israeli-Lebanese war and clinical relapses and MRI disease activity among Lebanese MS patients. METHODS We studied ...