Further studies of hereditary patent ductus arteriosus (PDA) in the dog show the defect to have a graded phenotypic expression. A high proportion of offspring of test matings had a fully patent ductus arteriosus, while a smaller proportion had a blind diverticulum of the ductus arteriosus which communicated with the aorta. This is considered to be a forme fruste of PDA, representing incomplete ...

OBJECTIVE Systemic-to-pulmonary shunt operations are still required for palliation of certain congenital heart defects. The aim of this study was to analyze the incidence and etiology of the development of pulmonary artery stenosis after these procedures. METHODS AND RESULTS Pre- and post-operative angiograms of 59 patients who underwent 54 peripheral and 12 central shunt operations were anal...

OBJECTIVE To identify clinical and echocardiographic indicators of the necessity for early surgical closure of patent ductus arteriosus in preterm neonates. METHODS The prospective study was conducted at the Neonatal Unit of Hospital Municipal Odilon Behrens between 2006 and 2010. The study population comprised 115 preterm neonates diagnosed with patent ductus arteriosus in the first week aft...

Inhibitors of the cyclo-oxygenase component of prostaglandin-H2 synthetase, namely indomethacin and ibuprofen, are commonly used in the treatment of hemodynamically significant patent ductus arteriosus. These drugs are associated with serious adverse events, including gastrointestinal perforation, renal failure and bleeding. The role of paracetamol, an inhibitor of the peroxidase component of p...

T HE most frequent cardiovascular anomaly following maternal rubella is patent ductus arteriosus.1-0; The majority of patients with typical signs of patent ductus arteriosus are treated surgically without special diagnostic studies such as cardiac catheterization and angiocardiography. In these individuals residual systolic murmurs may persist and are often attributed to mild pulmonary valvular...

After birth, constriction of the full-term ductus arteriosus induces oxygen, glucose and ATP depletion, cell death, and anatomic remodeling of the ductus wall. The immature ductus frequently fails to develop the same degree of constriction or anatomic remodeling after birth. In addition, the immature ductus loses its ability to respond to vasoconstrictive agents, like oxygen or indomethacin, wi...

Surgical closure of patent ductus arteriosus in adults involves a number of risks because there are associated anatomic and histologic alterations. Between October 1992 and August 2008, 23 patients were referred to our department with isolated patent ductus arteriosus. Their age ranged from 16-75 years (median 25.5 years) and their weight from 52-80 kg (median 57 kg). The pulmonary diameter ran...

normal healthy children.4 The association between the fall in atrial natriuretic peptide concentration and decrease in body weight after volume reduction by haemodialysis suggests that in children volume expansion releases atrial natriuretic peptide. In preterm infants plasma atrial natriuretic peptide concentrations are considerably raised on the second day of life and decrease to normal withi...

Background Patent ductus arteriosus is a common congenital disorder (10% of congenital disorders). Ductus Botalli closure is the realm of invasive cardiology. Inability to perform ductus Botalli closure with percutaneous methods causes, that administration of indomethacin or surgery are nowadays treatment of choice. The aim is to present an alternative in treatment with minimally invasive surge...

Indomethacin produces constriction and hypoxia of the fetal ductus arteriosus. This is associated with death of smooth muscle cells in the ductus wall and an increased incidence of patent ductus arteriosus in the newborn period. We used fetal sheep to determine which factors are responsible for indomethacin-induced hypoxic cell death. Cell death in the ductus wall is directly related to the deg...