In recent years, more and more publications and material for studying and teaching, e. g. for Web-based teaching (WBT), appear "online" and digital libraries are built to manage such publications and online materials. Therefore, the most important concerns are related to the problem of durable, sustained storage and the management of content together with its metadata existing in heterogeneous ...

The long life and low usage of archival data make cost considerations paramount. Today, most archival storage architectures depend on magnetic or optical media such as tape and disk because they have a low initial cost per byte. The high initial cost of storage class memories (SCMs) has been seen as prohibitive for archival use. Nevertheless, SCMs have many advantages for archival use, includin...

The paper presents a case study where the energy demand for a listed building constructed in 1900 is reduced. Many older buildings are listed and have restrictions that include the entire building or that include only its exterior. For the building presented, only its exterior facade is listed. The paper demonstrates measures for the improvement of the thermal insulation of the building with so...

Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses are defining the molecular architecture of GBM, uncovering relevant subsets of patients whose disease may require different treatments. Many pharmacological targets have been revealed, promising to transform patient care through targeted therapies. However, for most patients, clinical responses to targeted inhibitors a...

There is a lack of durable thinking on digital longevity. For this we require cross-domain communication and acceptation of standardized concepts, procedures, document formats and IT-tools. Four kinds of standards are required for preservation of digital documents over an indefinite period of time: standards for the architecture, document format standards for preservation, metadata standards fo...

Neurons live for decades in a postmitotic state, their genomes susceptible to DNA damage. Here we survey the landscape of somatic single-nucleotide variants (SNVs) in the human brain. We identified thousands of somatic SNVs by single-cell sequencing of 36 neurons from the cerebral cortex of three normal individuals. Unlike germline and cancer SNVs, which are often caused by errors in DNA replic...

In highly reliable and durable systems, failures due to aging might result in catastrophes. Aging monitoring techniques to prevent catastrophes by predicting such a failure are required. Aging can be monitored by performing a delay test at faster clocks than functional clock in field and checking the current delay state from the test clock frequencies at which the delay test is passed or failed...

We report on the implementation of a software infrastructure for preservation actions, carried out in the context of the European Integrated Project Planets – the Planets Interoperability Framework (IF). The design of the framework was driven by the requirements of logical preservation in the domain of libraries and archives, which include durable and scalable infrastructures for the characteri...

In this paper we examine the influence that indirect network effects have on a durable goods manufacturer’s distribution strategy to lease or sell her product. Previous research has identified that a durable goods manufacturer can mitigate the potential for its own opportunistic behavior with respect to consumers by leasing instead of selling its product. However, we show that leasing creates a...