abstract objective: diabetic peripheral neuropathy is the main risk factor of diabetic foot ulcer and its early diagnosis is important to prevent limb amputation. we assessed the prevalence of peripheral neuropathy in diabetic patients. materials and methods: this cross-sectional study was performed on 352 randomly selected diabetic patients using a standardized questionnaire including age, gen...

trade relationships built through production chains appear to be lasting due to relation-specific nature of the transactions, compared with the usual transactions of goods sold on the open market. this paper aims to verify such stability of international production networks at the global level, with special emphasis on intra-east asian trade. a series of survival analyses provide an evidence su...

This study identifies governance patterns for information technology investment decision processes and explores the impact of organizations’ investment characteristics, external Bernard Tan was the accepting senior editor for this paper. Christina Soh was the associate editor. Ranganathan Chandrasekaran and Albert Boonstra served as reviewers. The third reviewer chose to remain anonymous. envir...

The purpose of the article is to analyze role intellectuals in political life France based on study views and state activities famous French historian figure François Guizot (1787–1874). author examines relationship between historical Guizot, his understanding main problems European history, public during Restoration (1814–1830) July Monarchy (1830–1848). theme intelligentsia power most vividly...

Both the amino-terminal and carboxyl-terminal domains of IGF binding protein (IGFBP)-3 are believed to contribute to high-affinity IGF binding. To investigate cooperativity in IGF binding by these domains, we expressed IGFBP-3 fragments 1-88 (NBP-3) and 185-264 (CBP-3) as FLAG and hexahistidine-tagged fusion proteins, respectively. IGF-I and IGF-II bound to NBP-3 poorly and to CBP-3 with modera...

Hairy root culture is a potential alternative to conventional mammalian cell culture to produce recombinant proteins due to its ease in protein recovery, low costs and absence of potentially human pathogenic contaminants. The current study focussed to develop a new platform of a hairy root culture system from Nicotiana tabacum for the production of recombinant human EPO (rhEPO), which is regula...

Ischemia and reperfusion of organs is an unavoidable consequence of transplantation. Inflammatory events associated with reperfusion injury are in part attributed to excessive complement activation. Systemic administration of complement inhibitors reduces reperfusion injury but leaves patients vulnerable to infection. Here, we report a novel therapeutic strategy that decorates cells with an ant...

We had earlier identified the pcnB locus as the gene for the major Escherichia coli poly(A) polymerase (PAP I). In this report, we describe the disruption and identification of a candidate gene for a second poly(A) polymerase (PAP II) by an experimental strategy which was based on the assumption that the viability of E. coli depends on the presence of either PAP I or PAP II. The coding region t...