Buccoadhesive tablets of Metclopramide Hydrochloride were fabricated with objective of avoiding extensive first pass metabolism and to prolong its duration of action with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Chitosan, HPMC K4M and HPMC K15M. Tablets were prepared by direct compression method using polymer in different ratios. The ...

Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produc...

We propose a new method for creating an optimal coherence in a two-level system (TLS) based on adiabatic following. Optimal coherence is achieved by choosing the time-dependent phase of the pulse that provides vanishing field-TLS detuning dðtÞ at central time when the pulse amplitude reaches maximum. For example, dðtÞ 1⁄4 d0ð1 expððt t0Þ=s0ÞÞ for t 6 t0 and d 1⁄4 0 for t > t0. The pulse envelop...

There are various types of lasers available for hair reduction, but the choice of an ideal laser for ethnic skin has its own limitations. The choice of the right laser for the right skin type is very important. Before starting with the laser therapy, it is important to assess the skin type, the fluence, the pulse duration and the type of laser to be used.

conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

background: oral contraceptive pills are among the most popular contraceptive methods, but the fear of cancer and cardiovascular disease overshadows its continuous use among women. this study aimed to define the association between consumption patterns of combined oral contraceptives among women with breast cancer. materials and methods: this is an analytical case–control study conducted on 175...

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (CP) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation metho...

We developed novel acrylic-based polymers that can be used as mucoadhesive delivery systems. Poly(acrylic acid) hydrogels were modified by grafting adhesion promoter chains such as poly(ethylene glycol) (PEG) onto their back-bone chains, thus promoting the adhesive process by interpenetration. The copolymers synthesized were designated as P(AA-g-EG). Hydrogels were synthesized using PEG of two ...

Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose,...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...