Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing particularly on signals mediated by small GTPases ...

Formation of biofilm within a porous matrix reduces the pore size and the total open space of the system, altering the porosity and permeability of the medium. This change in the pore size distribution can be quantified by expressing the porous structure with a proper geometrical model. A set of pertinent multispecies biofilm models is used to arrive at the dynamic biofilm thickness distributio...

Wettability is a pore-scale property that impacts the relative movement and distribution of fluids in porous medium. There are reservoir provoke surface within pores to undergo wettability change. This change, turn, alters dynamics permeabilities at Darcy scale. Thus, modeling impact change essential understand interaction media. In this study, we include time-dependent into permeability–satura...

We make an analytical study of the nonsteady flow of Newtonian fluids in microchannels. We consider the slip boundary condition at the solid walls with Navier hypothesis and calculate the dynamic permeability, which gives the system's response to dynamic pressure gradients. We find a scaling relation in the absence of slip that is broken in its presence. We discuss how this might be useful to e...

Material and methods 13 patients with histopathologically proven oesophageal adenocarcinoma underwent a combined dynamic and static F-FDG PET/CT including CT tumour perfusion (Siemens, Biograph mCT). Dynamic PET (listmode) was acquired for 60 min resulting in 38 frames from 10 to 600 sec duration for the full dynamic dataset and 2 frames each with 600 sec duration (20-30 min and 50-60 min p.i.)...

Objective.Chlorhexidine gluconate (CHX) is an irrigant with a  reasonable antibacterial ability and rather high permeability yet often fails to remove the smear layer. To solve this problem, CHX is upgraded through its complexion with chitosan (CS). Methods.Molar roots are split longitudinally by a rotary diamond saw. Chlorhexidine-chitosan (CHX-CS) is made by combinatio...

PURPOSE Dynamic contrast-enhanced imaging provides unique physiological information, notably the endothelial permeability (K(trans)), and may improve the diagnosis and management of multiple pathologies. Current acquisition methods provide limited spatial-temporal resolution and field-of-view, often preventing characterization of the entire pathology and precluding measurement of the arterial i...

The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally, its functioning and structure also change dynamically in a depth-dependent manner. While transepidermal water loss is typically used to as...

Permeability of tumor vasculature can be a major barrier to successful drug delivery, particularly for high molecular weight agents such as monoclonal antibodies and their diagnostic or therapeutic conjugates. In this study, changes in permeability of SCCVII tumor vessels after radiation treatment were evaluated by dynamic magnetic resonance imaging as a function of time after irradiation using...

In this work, studies of underground gas storage (UGS) were performed on a partially depleted, naturally fractured gas reservoir through compositional simulation. Reservoir dynamic model was calibrated by history matching of about 20 years of researvoir production. Effects of fracture parameters, i.e. fracture shape factor, fracture permeability and porosity were studied. Results show...