PURPOSE We evaluated the diagnostic performance of histogram analysis of data from a combination of dynamic susceptibility contrast (DSC)-MRI and dynamic contrast-enhanced (DCE)-MRI for quantitative differentiation between central nervous system lymphoma (CNSL) and high-grade glioma (HGG), with the aim of identifying useful perfusion parameters as objective radiological markers for differentiat...

PURPOSE: Dynamic contrast enhanced (DCE) MRI requires high spatial resolution for morphological information and high temporal resolution for contrast pharmacokinetic modeling. The current fast imaging techniques [1-5] have shown success in improving the temporal resolution of DCE-MRI. However, it is still challenging to improve both the spatial and temporal resolutions simultaneously. This abst...

In Dynamic Contrast Enhanced Resonance Imaging (DCE-MRI), abdomen is scanned repeatedly and rapidly after injection of a contrast agent. During data acquisition, collected images suffer from the motion induced by the patient if he/she moves or breathes heavily during the scan. Therefore, these images should be aligned accurately to correct the motion. Recently, mutual information (MI) registrat...

Rupture of a vulnerable atherosclerotic plaque of the carotid artery is an important underlying cause of clinical ischemic events, such as stroke. Abundant microvasculature has been identified as an important aspect contributing to plaque vulnerability. Plaque microvasculature can be studied non-invasively with dynamic contrast-enhanced (DCE-)MRI in animals and patients. In recent years, severa...

CID map (similar results obtained for CIR and inclination maps) obtainable in as little as one minute following CA injection, compared to (b) T2w and (c) SSFP imaging that visualize a more homogeneous lesion. (d) Delayed enhancement imaging acquired many minutes post-contrast injection demonstrate similar lesion core and border regions after subtraction with pre-contrast data. a b c d VISUALIZA...

Dynamic contrast-enhanced MRI is becoming a standard tool for imaging-based trials of anti-vascular/angiogenic agents in cancer. So far, however, biomarkers derived from DCE-MRI parameter maps have largely neglected the fact that the maps have spatial structure and instead focussed on distributional summary statistics. Such statistics-e.g., biomarkers based on median values-neglect the spatial ...

The quantification of bolus-tracking MRI techniques remains challenging. The acquisition usually relies on one contrast and the analysis on a simplified model of the various phenomena that arise within a voxel, leading to un-accurate perfusion estimates. To evaluate how these simplifications impact perfusion estimates, we propose a versatile numerical tool to simulate the MR signal provided by ...