– A self-consistent variational theory for globules based on the uniform expansion method is presented. This method, first introduced by Edwards and Singh to estimate the size of a self-avoinding chain, is restricted to a good solvent regime, where two-body repulsion leads to chain swelling. We extend the variational method to a poor solvent regime where the balance between the two-body attract...

Elastic fibers are responsible for the extensibility and resilience of many vertebrate tissues, and improperly assembled elastic fibers are implicated in a number of human diseases. It was recently demonstrated that in vitro, cells first secrete tropoelastin into a punctate pattern of globules. To study the dynamics of macroassembly, that is, the assembly of the secreted tropoelastin globules i...

Partially folded protein species transiently form during folding of most proteins. Often, these species are molten globules, which may be on- or off-pathway to the native state. Molten globules are ensembles of interconverting protein conformers that have a substantial amount of secondary structure, but lack virtually all tertiary side-chain packing characteristics of natively folded proteins. ...

The C5a complement fragment is a potent inflammatory molecule but its contribution to the inflammatory response of the mammary gland remains uncertain. One of the unresolved questions is the possible interference of whole milk with C5a. In this study, the chemotactic activity ofpurifled bovine C5a was tested in the presence of whole or skimmed milk. Milk from healthy glands acted as a chemoattr...

Amyloid proteins of different aminoacidic composition share the tendency to misfold and aggregate in a similar way, following common aggregation steps. The process includes the formation of dimers, trimers, and low molecular weight prefibrillar oligomers, characterized by the typical morphology of globules less than 10 nm diameter. The globules spontaneously form linear or annular structures an...

Juvenile xanthogranuloma(JXG) is the variant of non-Langerhans' cell histiocytosis. The orange-yellow background coloration with clouds of paler yellow deposits is the most characteristic dermoscopic finding of JXG. Other dermoscopic features include erythematous border, subtle pigment network and white linear streak. The objective of this study was to present the structural correlation between...

abstract: influence of both dietary and bath administration of eucalyptus globules labill was evaluated on some immunological variables of common carp (cyprinus carpio) under temperature less than optimum in order to determine stimulatory effect of the essential oils. fish weighing 30-35 g were bathed or fed with different doses of 30, 60 and 120 |m|l/l or mg/kg feed for a period of 8 days. ser...

© 2017 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow A 24‐year‐old man presented with a single asymptomatic reddish‐brown annular plaque of 8‐months duration over the outer right arm [Figure 1]. Dermoscopy revealed a central homogenous skin‐colored to pale area with brown‐colored dots, globules, and an irregular double‐marginated track‐like border, most prominent aroun...

In a previous paper we demonstrated that nonradial hydrodynamic oscillations of a thermally supported (BonnorEbert) sphere embedded in a low-density, high-temperature medium persist for many periods. The predicted column density variations and molecular spectral line profiles are similar to those observed in the Bok globule B68, suggesting that the motions in some starless cores may be oscillat...

This study reveals the lateral organisation ofthe milk fat globule membrane (MFGM). Using confocal laser scanning microscopy (CLSM) and a lipid soluble molecule, an exogenous phospholipid and two lectins as fluorescent probes we located triacylglycerols in the core of fat globules and investigated the organisation of the polar lipids and glycoproteins of the MFGM, in situ in milk, Lipid rafts c...