The progressive rise in multidrug-resistant (MDR) bacterial strains poses serious problems in the treatment of infectious diseases. While the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. This rise in resistance illustrates the need for developing novel therapeutic and preventive antimic...

Nigella sativa (family Ranunculaceae) is an annual plant that has been traditionally used on the Indian subcontinent and in Middle Eastern countries. In this study, we investigated the effect of N. sativa oil on the drug-metabolizing cytochrome P450 (CYP) enzymes and whether it has a protective effect against the acute hepatotoxicity of CCl4. Intraperitoneal injection of rats with CCl4 drastica...

BACKGROUND In the present study the effect of Nigella sativa (N. sativa) ethanolic extract on cytokine profile in control, moderate and overtrained heavy exercised rat was examined. METHODS Male Wistar rats were randomly divided into control sedentary (C), moderate trained (MT), (V = 20 m/min, 30 min/day, 6 days a week, for 8 weeks), overtrained (OT) (V = 25 m/min, 60 min/day, 6 days a week, ...

OBJECTIVES Nigella sativa (N. sativa) is an amazing herb which is used in traditional medicine for a wide range of illnesses including bronchial asthma, dysentery, gastrointestinal problems, as well as beneficial effect on blood lipids, lowering blood pressure, serum cholesterol, and triglycerides level. This study aimed to determine the toxic effect of N. sativa powder on the kidney function w...

Alelopatia é considerada um acontecimento de ocorrência natural, que tem como resultado a liberação substâncias químicas e/ou metabolismos secundários distribuídas em concentrações variadas nos diversos órgãos vegetais das plantas durante o seu ciclo vida e podem inibir desenvolvimento fisiológico outras espécies. A espécie Croton heliotropiifolius Kunth, pertence à família Euphorbiaceae, sido ...

OBJECTIVES Aging is an unconscious and gradual process that can lead to changes in biological systems. Induction of oxidative stress and apoptosis, hepatotoxicity and neurotoxicity are involved in the aging process. Regarding the antioxidant property of black seed oil, the aim of this study was to evaluate the anti-aging effect of Nigella sativa (N. sativa) oil on d-galactose-induced aging in m...

Introduction: Amphotericin B is considered as one of the most effective antifungal drugs presently used to treat systemic fungal infections; however, nephrotoxicity remains the major side effect. The current study is therefore, designed to determine Amphotericin B induced nephrotoxicity and its prevention by administration of Nigella sativa (NS) extract in albino mice. Materials and Methods: Th...

OBJECTIVE Inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. Curcuma longa (C. longa) and Nigella sativa (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the oxidative stress induced by Adriamycin (ADR) in rat kidney. MATERI...

OBJECTIVES There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. The present study was aimed to evaluate scolicidal effects of various extracts of Nigella sativa seeds against protoscoleces of hydatid cyst in an in vitro model. MATERIALS AND...

Nigella sativa Linn. (Ranunculaceae) (N. sativa), commonly known as black seed or black cumin, is an herbaceous plant, mainly grows in the Middle East, Central Europe and Western Asia. It is widely used in indigenous system of medicine for treatment of numerous disorders for over 2 000 years[1-3]. Its seed oil had been widely used in Arab traditional of medicine for the treatment of arthritis, ...