We appreciated the article by Gonnert and colleagues on hyperbilirubinemia from septic hepatocellular excretory dysfunction [1], a still improperly characterized issue in clinical settings. We address postoperative liver resection patients with prominently conjugated (~50 to 70 % conjugated) hyperbilirubinemia. Less relevant causes include transient insufficiency of remnant liver and prolonged ...

OBJECTIVE The purpose of our study was to assess the predictors of early mortality after the creation of transjugular intrahepatic portosystemic shunts (TIPS) for acute variceal bleeding in patients with viral liver cirrhosis. MATERIALS AND METHODS Seventy-three patients (56 men and 17 women; mean age, 51.3 years) with viral liver cirrhosis who underwent TIPS placement for acute variceal blee...

clofibrate is a glucuronosyl transferase inducer that has been proposed to increase the elimination of bilirubin in neonates with hyperbilirubinemia. this study was conducted to determine the therapeutic effect of clofibrate in term neonates with non-hemolytic jaundice. this study was conducted on 52 newborns with pathologic unconjugated jaundice in qazvin children hospital. newborns divided ra...

Jaundice is a clinical condition that is often present is pediatric practice and constitutes one of the major issues within the neonatal period. Although most newborn with jaundice are otherwise healthy, they need to be monitored because bilirubin is potentially toxic to central nervous system .A prospective cohort study was conducted in Neonatal intensive care unit of Gauhati medical college a...

The aim of this study was to investigate the genotypic distribution of organic anion transporting polypeptide 2 (OATP-2) gene mutations and the relationship with hyperbilirubinemia of unknown etiology. Polymerase chain reaction, restriction fragment length polymorphism, and agarose gel electrophoresis techniques were used for detection of OATP-2 gene mutations in 155 newborn infants: 37 with un...

OBJECTIVE to prospectively validate a previously constructed transcutaneous bilirubin (TcB) nomogram for identifying severe hyperbilirubinemia in healthy Chinese term and late-preterm infants. METHODS this was a multicenter study that included 9,174 healthy term and late-preterm infants in eight hospitals of China. TcB measurements were performed using a JM-103 bilirubinometer. TcB values wer...

The antiretroviral agent atazanavir is associated with mild asymptomatic hyperbilirubinemia. We report two cases of symptomatic hyperbilirubinemia attributed to atazanavir in conjunction with the Pneumocystis jirovecii pneumonia prophylaxis agent dapsone. Symptoms and laboratory evidence of hemolysis resolved upon discontinuation of dapsone, enabling successful antiretroviral therapy. Symptomat...