Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations.We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive- C reactive protein(hs-CRP) in prediction of early neonatal sepsis.A follow-up study was performed on 95 neonates who were below 12 hours (h) of age...

BACKGROUND Initial cardiovascular responses during sepsis are characterized by hyperdynamic circulation. Although studies have shown that a novel potent vasodilatory peptide, adrenomedullin (ADM), is up-regulated under such conditions, it remains unknown whether ADM is responsible for initiating the hyperdynamic response. OBJECTIVE To determine whether increased ADM release during early sepsi...

INTRODUCTION Invasive meningococcal disease can be difficult to detect early in its course when patients may appear well and the severity of their illness is obscured by non-specific complaints. CASE PRESENTATION We report five cases of meningococcal sepsis in adult patients who presented to an emergency department early in the course of their disease, but whose severity of illness was not re...

conclusions the high prevalence of fungaemia and mortality could be attributed to many patients on chronic immunosuppressive therapy. nonetheless, cpfa albeit expensive, does add to our armamentarium of extracorporeal treatment for severe sepsis. regional citrate anticoagulation with cpfa may overcome problems with filter clotting. objectives the main objective was to review our centers' e...

Meningitis, pneumonia, and sepsis in newborns and young infants (age < 60 days) are the main causes of childhood mortality in developing countries. Even though streptococcus pneumonia is the most commonly detected microorganism in pediatric bacterial meningitis, it is rare in newborn infants. The following article reports a case of pneumococcal meningitis that was detected early in a newborn in...

Critical Care Medicine www.ccmjournal.org 2263 EARLY INTERVENTIONS IMPROVE OUTCOME Sepsis in the year 2016 remains the most expensive disease treated in hospitals and is the most common cause of in-hospital deaths in the United States (1). However, over the last 15 years, since the introduction of early goal-directed therapy (EGDT) and the Surviving Sepsis Campaign (SSC), there has been a consi...

BACKGROUND Sepsis is a serious and often fatal clinical syndrome, resulting from infection. Information on patient demographics, risk factors, and infections leading to sepsis is needed to integrate comprehensive sepsis prevention, early recognition, and treatment strategies. METHODS To describe characteristics of patients with sepsis, CDC and partners conducted a retrospective chart review i...

BACKGROUND Sepsis is a common cause of death throughout the world. Early treatment improves outcome; however, treatment may be delayed if the patient does not present himself/herself for medical care until late in the disease process. Lack of knowledge about the syndrome may contribute to delay in presenting for medical care. However, we need to acknowledge the complexity of sepsis. General awa...

BACKGROUND Early diagnosis of neonatal sepsis followed by appropriate treatment decreases mortality and morbidity in infants. The aim of this study is to assess the role of procalcitonin (PCT) as a marker in the early diagnosis of neonatal sepsis. METHODS We present a cross sectional study where 35 neonates with early onset sepsis (admitted to the Neonatal Intensive Care Units at El-Minia Chi...

This article is a brief overview of empiric antibiotic selection for sepsis and septic shock. The article includes a differential diagnosis of the mimics of sepsis and stresses a strategy for avoiding problems associated with antibiotic resistance. Although early appropriate empiric therapy is the cornerstone of sepsis and septic shock therapy, nonantibiotic interventions are critical as well. ...