Multilamellar phosphatidylcholine liposomes (0.1 pmol) and 1 : 1 phosphatidylcholinecholesterol multilamellar liposomes (0.094pmol) were incubated with 2 x lo6 unstimulated CBA mouse peritoneal macrophages in Fisher's medium. A, Phosphatidylcholine liposomes+macrophages ; 0, phosphatidylcholine liposomes alone; A, phosphatidylcholins-cholesterol liposomes+maaophages; 0, phosphatidylcholin~holes...

Background: Non-viral Nano carriers such as liposomes and cationic polymers based on engineered properties are regarded in gene delivery field. Although these carriers do not have weaknesses of viral vectors, but they are less efficient than viruses and they still need to be improved as favorable gene delivery carriers. Amongst non-viral carriers, cationic liposomes have been proposed for clini...

The obtaining of nanocarriers gene material and small drugs is still an interesting research line. Side-effects produced by the toxicity several pharmaceutics, high concentrations needed to get therapeutic effects, or their excessive use patients have motivated search for new nanostructures. For these reasons, cationic metallo-liposomes composed phosphatidylcholine (PC), cholesterol (CHO) RuC1C...

The purpose of this study is to evaluate in vitro gene delivery mediated by asialofetuin-appended cationic liposomes (AF-liposomes) associating cyclodextrins (CyD/AF-liposomes) as a hepatocyte-selective nonviral vector. Of various CyDs, AF-liposomes associated with plasmid DNA (pDNA) and γ-cyclodextrin (γ-CyD) (pDNA/γ-CyD/AF-liposomes) showed the highest gene transfer activity in HepG2 cells wi...

Caribbean patients [1]. HIVAN is associated with Case report proteinuria, disproportionately low albumin relative to the degree of peripheral oedema and rapid progression A 36-year-old male Ugandan refugee presented to to end-stage renal disease in 4–16 months. HIVAN casualty with a 2-month history of pyrexia, night can present at any stage of HIV disease and even be sweats, weight loss, malais...

Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers enclosing an aqueous core. Being both nontoxic and biodegradable, liposomes represent a powerful delivery system for several drugs. They have improved the therapeutic efficacy drugs through stabilizing compounds, overcoming obstacles to cellular tissue uptake increasing drug biodistribution target sites ...

The objective of this work was to evaluate the physical properties and in vivo circulation of chitosan (CH)-coated liposomes of mitoxantrone (MTO). Changes in particle size and zeta potential confirmed the existence of a coating layer on the surface of liposomes. The in vitro release of adsorbed CH from the liposomes was significantly slower than CH solution, indicating the stable interaction b...

Hyaluronan-grafted liposomes (HA-liposomes) preferentially target CD44-overexpressing tumor cells in vitro via receptor-mediated endocytosis. We investigated the pharmacokinetics and biodistribution of HA-liposomes with various sizes of HA (MW 5-8, 50-60, and 175-350 kDa) in mice. Incorporation of negatively charged HA on the liposome surface compromised its blood circulation time, which led to...

Liposome-based drug delivery systems hold great potential for cancer therapy. However, to enhance the localization of payloads, an efficient method of systemic delivery of liposomes to tumor tissues is required. In this study, we developed cationic liposomes composed of polyethylenimine (PEI)-conjugated distearoylglycerophosphoethanolamine (DSPE) as an enhanced local drug delivery system. The p...