•CRISPR-Cas9 screens of human ubiquitin pathway components across 41 conditions•Dozens reported interactions validated independently•Loss FBXO42 causes pronounced sensitivity to inhibitors mitosis•FBXO42 plays a role in successful completion mitosis The proteasome system, composed over 700 ligases (E3s) and deubiquitinases (DUBs), has been difficult characterize systematically phenotypically. W...

Induced protein degradation accomplishes elimination, rather than inhibition, of pathological proteins. Key to the success this novel therapeutic modality is modification proteins with ubiquitin chains, which brought about by molecular glues or bivalent compounds that induce proximity between target and an E3 ligase. The human genome encodes ?600 ligases differ widely in their structures, catal...

Working memory is crucial for many higher-level cognitive functions, ranging from mental arithmetic to reasoning and problem solving. Likewise, the ability to learn and categorize novel concepts forms an indispensable part of human cognition. However, very little is known about the relationship between working memory and categorization. This article reports two studies that related people’s wor...

The purpose of this study was to understand how dynamic classroom furniture may impact classroom performance such as attention, work neatness, and work completion in a second grade general education classroom of 19 students. All students in the classroom were included in this study to understand the implications of environmental modifications on the learning process in general education setting...

A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications, specifically the article signed by all Consortium members, put forward the idea that more than 80% of the human genome is functional. This claim flies in the face of current estimates according to which the fraction of the genome that is evolutionarily conserved through purifying selection is less than10%. Thus, acc...

The purpose of this study was to understand how dynamic classroom furniture may impact classroom performance such as attention, work neatness, and work completion in a second grade general education classroom of 19 students. All students in the classroom were included in this study to understand the implications of environmental modifications on the learning process in general education setting...

Occupational therapists and occupational therapy assistants rely on knowledge and skills to guide their intervention planning as they help clients who are experiencing difficulties with engaging in occupation. Sensory integration theory, with its rich history grounded in the science of human growth and development, offers occupational therapy practitioners specific intervention strategies to re...

Starting with the results of Li et al. in 1992 there is valuable interest in finding long range correlations in DNA sequences since it raises questions about the role of introns and intron-containing genes. In the present paper we studied two sequences that are the human T-cell receptor alpha/delta locus, Gen-Bank name HUMTCRADCV, a noncoding chromosomal fragment of M = 97630 bases (composed of...

Microbe associated molecular pattern (MAMP)-triggered immunity (MTI) is an important component of the plant innate immunity response to invading pathogens. However, most of our knowledge of MTI comes from studies of model systems with relatively little work done with crop plants. In this work, we report on variation in both the MAMP-triggered oxidative burst and gene expression across four soyb...