BACKGROUND Our goal was to assess the diagnostic value of creatine phosphokinase (CPK) and its isoenzyme CPK- muscle brain (MB) in ectopic pregnancy (EP) in order to locate a simpler diagnostic approach for EP. MATERIALS AND METHODS This was a prospective study that performed consecutive sampling for 20 months in two major hospitals in Isfahan, Iran. All pregnant patients in their first trime...

MicroRNAs are single stranded, non-coding, 19-25 nucleotide molecules which regulate messenger RNA stability and transcription. They important gene regulators their expression profiles change with pathophysiology. A fraction is shed into the circulation in a stable quantifiable form. Following initial microRNA discovery work that identified 19 microRNAs differential pregnancy of unknown locatio...

Partial or complete mole affects one in 1000  pregnancies.Partial mole is a rare form of ectopic pregnancy. There was a married woman,gravid 4,parity 1,abortion 1,and she had past medical history 0f right ectopic pregnancy.she had left ectopic pregnancy and was treated by laparascopic left salpyngectomy after failure of intramascular methotrexate treatment.After surgery  the pathology exam show...

The endometrium in early pregnancy undergoes decidualization and functional changes induced by local trophoblast, which are not fully understood. We hypothesized that endometrium from tubal ectopic pregnancy (EP) could be interrogated to identify novel genes and pathways involved in these processes. Gestation-matched endometrium was collected from women with EP (n = 11) and intrauterine pregnan...

BACKGROUND A logistic regression model (M4) was developed in the UK to predict the outcome for women with a pregnancy of unknown location (PUL) based on the initial two human chorionic gonadotrophin (hCG) values, 48 h apart. The purpose of this paper was to assess the utility of this model to predict the outcome for a woman (PUL) in a US population. METHODS Diagnostic variables included log-t...

BACKGROUND Fetal cells are shed from the regressing chorionic villi and it is possible to retrieve extravillous cytotrophoblast cells by transcervical sampling. The abundance of trophoblast cells in transcervical samples suggests that this non-invasive approach could distinguish between normal and abnormal pregnancies, such as an ectopic pregnancy (EP) and blighted ovum (BO). We aim to identify...

A rare clinical case of successful treatment an interrupted ovarian pregnancy (ОР), the incidence which is 0.4– 1.3 % all ectopic pregnancies (ЕР), described. The exact etiopathogenetic mechanism OP development still unknown. rupture mainly occurs in first trimester 91.0 %, second it 5.3 and third it’s 3.7 %. Untimely diagnosis EP ovaries can be fatal with massive bleeding associated risk ovari...

Activin A and related proteins (inhibins, follistatin [FS], follistatin-related gene [FLRG], endometrial bleeding associated factors [ebaf]) are involved in the complex mechanisms allowing the establishment and the maintenance of pregnancy. As a consequence of ovarian progesterone stimuli, activin A is expressed and secreted by the stromal endometrial cells, which locally induces the decidualiz...