نتایج جستجو برای: edaravone
تعداد نتایج: 529 فیلتر نتایج به سال:
In the ischemic brain, reperfusion with tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT); however, the mechanism remains elusive. Here, we show that the basement membrane, and not the endothelial cells, is vulnerable to ischemic/reperfusion injury with tPA treatment. We treated a spontaneously hypertensive rat model of middle cerebral artery occlu...
To investigate the role and mechanism of catalpol on neuroprotective effects and memory enhancing effects simultaneously, neuroprotective effects of catalpol were assessed by neurological deficits score, TTC staining, and cerebral blood flow detecting. Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central c...
Communication in today’s world is fast and ever accelerating. Until May 2017, however, it remained largely unnoticed on both sides of the North Atlantic that a new drug, edaravone (Radicava®, Mitsubishi Tanabe, Japan), for treating amyotrophic lateral sclerosis (ALS) was approved by the Pharmaceutical and Medical Device Agency in Japan on 26 June 2015. This delay is remarkable because pharmaceu...
The title compound, C(10)H(10)N(2)O, known as Edaravone (MCI-186), was crystallized from methanol. The two independent mol-ecules in the asymmetric unit are linked through an O-H⋯O hydrogen bond. One mol-ecule adopts a ketone form, while the other adopts an enol form. In the crystal structure, mol-ecules are linked through inter-molecular N-H⋯O hydrogen bonds, forming chains running along the b...
Ammar Al-Chalabi, Peter M. Andersen, Siddharthan Chandran, Adriano Chio, Philippe Corcia, Philippe Couratier, Olof Danielsson, Mamede de Carvalho, Claude Desnuelle, Torsten Grehl, Julian Grosskreutz, Trygve Holmøy, Caroline Ingre, Merete Karlsborg, Grethe Kleveland, Jan Christoph Koch, Blaz Koritnik, Magdalena KuzmaKozakiewicz, Hannu Laaksovirta, Albert Ludolph, Christopher McDermott, Thomas Me...
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