نتایج جستجو برای: effector target conjugate
تعداد نتایج: 471896 فیلتر نتایج به سال:
While yeast has been extensively used as a model system for analysing protein–protein and genetic interactions, in the context of bacterial pathogenesis, the use of yeastbased tools has largely been limited to identifying interactions between pathogen effectors and host targets. In their recent work, Ensminger and colleagues (Urbanus et al, 2016) use the combinatorial power of yeast genetics to...
We report herein the successful preparation of a compact and functional CdSe-ZnS core-shell quantum dot (QD)-DNA conjugate via highly efficient copper-free "click chemistry" (CFCC) between a dihydro-lipoic acid-polyethylene glycol-azide (DHLA-PEG-N3) capped QD and a cyclooctyne modified DNA. This represents an excellent balance between the requirements of high sensitivity, robustness and specif...
The obesity epidemic continues unabated and currently available pharmacological treatments are not sufficiently effective. Combining gut/brain peptide, GLP-1, with estrogen into a conjugate may represent a novel, safe and potent, strategy to treat diabesity. Here we demonstrate that the central administration of GLP-1-estrogen conjugate reduced food reward, food intake, and body weight in rats....
Hypoxia attenuates effector-target cell interaction in the airway and pulmonary vascular compartment
melanocortin-1 (mc1) receptor is an attractive melanoma-specific target for the development of α-msh peptide based imaging and therapeutic agents. in this work a new lactam bridge α-msh analogue was synthesized and radiolabeled with 99mtc via hynic chelator and tricine as co-ligand. also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...
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