Introduction: Beta-carboline alkaloids of P. harmala are shown to have immune-modulatory effects in several studies. Extracts of this plant have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including PGE2 and TNF-α. In postmortem studies, structural alterations to the cerebellum have been recognized, including Purkinje cell loss being re...

Capsaicin, the vanilloid that selectively activates vanilloid receptors (VRs) on sensory neurons for noxious perception, has been reported to increase cochlear blood flow (CBF). VR-related receptors have also been found in the inner ear. This study aims to address the question as to whether VRs exist in the organ of Corti and play a role in cochlear physiology. Capsaicin or the more potent VR a...

UNLABELLED Cochlear implantation has been recommended for children under 24 months of age. The use of objective measures is needed to help speech processor programming. The electrically evoked compound potential (EAP), which can be assessed by neural response telemetry (NRT), is one of those objective measures. AIM to determine how often the EAP can be recorded by NRT system during surgery an...

Gabapentin (GBP; Neurontin) has proven efficacy in several neurological and psychiatric disorders yet its mechanism of action remains elusive. This drug, and the related compounds pregabalin [PGB; CI-1008, S-(+)-3-isobutylgaba] and its enantiomer R-(-)-3-isobutylgaba, were tested in an in vitro superfusion model of stimulation-evoked neurotransmitter release using rat neocortical slices prelabe...

background and aim: vestibular migraine is a type of migraine that causes vertigo, dizziness, and imbalance in addition to typical migraine symptoms. in this study, we aimed to investigate vestibular system in these patients by videonystagmography (vng), electrocochleography (ecochg), and vestibular evoked myogenic potential (vemp) testing. methods: this empirical study was conducted on 10 pati...

1. Photic stimulation of the mature eye of Strombus can evoke in the optic nerve 'on' activity in numerous small afferent fibres and repetitive 'off' bursts of afferent impulses in a smaller number of larger fibres. 2. Synchronous invasion of the eye by electrically evoked impulses in small optic nerve fibres (apparently the 'on' afferents, antidromically activated) can evoke a burst of impulse...

Usually mathematicians use Hodgkin-Huxley model or FitzHug-Nagumo model to simulate action potentials of skeletal muscle fibers. These models are electrically excitable, but skeletal muscle fibers are stimulated chemically. To investigate skeletal muscle fibers we use a model with six ordinary differential equations. This dynamical system is sensitive to initial value of some variables so it is...

The effects of N,N-dimethyltryptamine on electrically evoked potentials in the visual system of the cat and the interaction of selected neuroleptic agents with ~ethyi~yp~mine were studied. Dimethyltryptamine caused a doss-dependent decrease in the amplitude of the response evoked by stimulation of the optic chiasm as recorded in the lateral geniculate nucleus and the visual cortex. Dimethyltryp...