An unexpectedly high incidence of abnormalities in the sulphobromophthalein (Bromsulphalein) excretion test, and to a smaller extent in other tests of liver function, was found in patients taking allopurinol and in those on uricosuric treatment. The reason for this is not apparent, but there is no evidence that either type of drug treatment was responsible. It is as yet uncertain whether allopu...

It is often said that angiocardiography carries little risk, and series of more than a thousand injections without a death are on record (Sussman, 1948; Horger et al., 1951). During recent years, however, more than thirty deaths have been reported-the majority in children with cyanotic congenital heart disease. The exact cause of these deaths has still to be discovered. When Mr. R. C. Brock beg...

Deficiency in thiamin, a factor of the vitamin B complex, may cause severe circulatory insufficiency. It is, therefore, of interest to study the circulation in another type of B-avitaminosis-pellagra. The circulatory disturbances encountered in pellagra are of no great clinical significance. Frequently low arterial pressure and tachycardia are present. CEdema, if there is any, can scarcely be a...

Signal processing today is performed in the vast majority of systems for ECG analysis and interpretation. The objective of ECG signal processing is manifold and comprises the improvement of measurement accuracy and reproducibility (when compared with manual measurements) and the extraction of information not readily available from the signal through visual assessment. In many situations, the EC...

Cardiomyopathy has been defined as "a subacute or chronic disorder of heart muscle of unknown or obscure etiology, often with associated endocardial, and sometimes with pericardial, involvement, but not atherosclerotic in origin". Using this definition a differentiation of chronic cardiomyopathies into three types has been made on clinical grounds (Goodwin et al., 1961). Obstructive Cardiomyopa...

The electrocardiographic tracing most familiar to physicians is the normal adult electrocardiogram. This tracing is remarkably stable once it assumes its mature stage and indeed one can use the electrocardiogram as a clear identifier of any one individual since, in the absence of intervening disease, the tracing remains identical when repeated again and again1. So stabIe is the electrocardiogra...

A NUMBER of reports on normal ranges of corrected orthogonal electrocardiographic measurements have appeared in the literature.'-12 They were derived, however, from limited numbers of subjects and the types of electrocardiographic and vectorcardiographic measurements varied largely from one study to another. The reported results are therefore not always strictly comparable. In spite of these li...

In clinical electrocardiography many attempts have been made to achieve a higher degree of accuracy in the interpretation. One controversial subject is whether unipolar chest leads are more useful than Latterly he tested a transthoracic lead with the indifferent electrode placed in the 4th intercostal space at the right sternal border (station 1) and the exploring electrode placed in the left p...