When Horsley and Clarke8 introduced their stereotaxic manipulator in 1908, all subcortical areas in the brains of laboratory animals theoretically became accessible for study. As a consequence, many valuable data have been obtained from stimulation and ablation studies. The potential of the technique for ablation study has been limited for want of a necrotizing agent that would gradually destro...

The effects of bilateral electrolytic subicular lesions were examined on the operant behaviour for food reward on a continuous reinforcement schedule as well as the dendritic morphology of CA1 and CA3 hippocampal areas. The subjects were female Wistar rats 20 days of age and were divided into four groups. 1. Age matched control 2. Sham operated 3. Operant behaviour for food reward and 4. Subicu...

in many hydroelectric dams, when the inflows are greater than the demand for energy, a portion of the water that could be used to generate electricity is diverted to the spillway and literally wasted. this energy,designated as “spilled turbinable energy”, could be used advantageously to generate other products or an energy vector that could be stored for later use, since in these situations the...

OBJECTIVE The purpose of this study was to retrospectively evaluate and compare the incidence of diffusion-weighted image (DWI) lesions between the Guglielmi detachable coil (GDC) and the Target coil for treating unruptured intracranial aneurysm. METHODS From 2010 to 2011, consecutive 222 patients with an intracranial aneurysm underwent coil embolization. Inclusion criterias were : 1) unruptu...

The objective of this study was to determine if ablation of the lateral parabrachial nucleus (LPBN) would prevent angiotensin II-induced hypertension in rats. Thirteen male Sprague-Dawley rats were studied. Bilateral electrolytic lesions in the LPBN were produced in six rats; the remaining seven rats were subjected to sham lesion surgery only. All rats were instrumented with vascular catheters ...

Background Ketamine rapidly elicits antidepressive effects in humans and mice in which serotonergic activity is involved. Although α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) in the dorsal raphe nucleus plays a key role in the ketamine-induced prefrontal serotonin release, the source of cholinergic afferents, and its role is unclear. Methods Prefrontal serotonin levels after ketamine i...

Cats were trained to press on a lever either fixed or moving at different speeds from left to right or right to left at random. In the first series of animals, the following bilateral lesions were performed after reaching criterion on the moving lever: (1) deep cutting of cortico-cortical fibers connecting visual and frontal cortex; (2) subtotal electrolytic destruction of n. ventralis laterali...

The effects of bilateral electrolytic lesions of the "shell" subterritory of the nucleus accumbens in the rat were examined on 2 tasks known to be sensitive to hippocampal damage. Experiment 1 tested the effects of shell lesion on delayed non-matching-to-sample (DNMS) task in a T-maze. The maze was rotated 180 degrees after the end of acquisition. Experiment 2 used a 4-arm baited, 4-arm unbaite...