Usher syndrome is a group of autosomal recessive diseases characterized by congenital deafness and retinitis pigmentosa. In a mouse model for Usher syndrome, KMush/ush, discovered in our laboratory, we measured the phenotypes, characterized the architecture and morphology of the retina, and quantified the level of expression of pde6b and ush2a between postnatal (P) days 7, and 56. Electroretino...

PURPOSE It has been reported that the second-order kernel response components of multifocal electroretinograms (mERGs) reflect the electrical activity of the inner retinal layers. In this study, we have investigated whether the amplitudes of the second-order kernel response components correlate with the spatial distribution of human retinal ganglion cells. METHODS Multifocal electroretinogram...

The ocular disposition and toxicity of GEM132, a mixed backbone phosphorothioate oligonucleotide developed for the treatment of cytomegalovirus-induced retinitis, were studied in rabbits for 6 months following single intravitreal injection of 5, 20, or 100 microgram/eye (toxicity) and 3.7, 15.7, or 78.5 microgram/eye (disposition). Intraocular pressure, electroretinograms, and ophthalmoscopy we...

Purpose We determined whether the chronic lack of optic nerve myelination and subsequent axon loss is associated with optical coherence tomography (OCT) changes in the retinal nerve fiber layer (RNFL), and whether this models what occurs in multiple sclerosis (MS) and confers its use as a surrogate marker for axon degeneration. Methods Using an animal model of Pelizaeus-Merzbacher disease (sh...

AIM: To evaluate the changes in fundus parameters patients with Alzheimer’s type dementia (ATD) using optical coherence tomography angiography (OCTA), to record flash electroretinograms (ERG) RETeval system and explore retinal function. METHODS: Twenty-nine ATD 26 age-matched normal subjects were enrolled. All underwent OCTA scans analyse superficial vessel macular area, including length densit...

PURPOSE To demonstrate that silent substitution stimuli can be used to generate electroretinograms (ERGs) that effectively isolate rod photoreceptor function in humans without the need for dark adaptation, and that this approach constitutes a viable alternative to current clinical standard testing protocols. METHODS Rod-isolating and non-isolating sinusoidal flicker stimuli were generated on ...

The retinal response to particular orientations might start a signaling cascade of events that help modulate eye growth and respond myopia control treatments. purpose this study was investigate the electrical activity in grids different spatial orientations. multifocal (mfERG) pattern (PERG) ERG responses nine eyes (spherical equivalent −0.45 ± 1.15 D; mean age 32.9 7.7 years) were recorded wit...