ABSTRACT We describe an integrated microchip for droplet analysis with electrospray ionization mass spectrometry (ESI-MS). The chip integrated multiple modules of droplet generator, droplet extraction interface, and monolithic ESI-emitter. A novel droplet extraction interface based on a hydrophilic tongue structure was developed to transfer droplet from segmented phase to aqueous phase with hig...

We describe a new practical capillary electrophoresis/electrospray ionization-mass spectrometry (CE/ESI-MS) method for the forensic analysis of phosphorus-containing amino acid-type herbicides, glyphosate (GLYP), glufosinate (GLUF) and bialaphos (BIAL). A new sheathless interface, a high sensitivity porous sprayer (HSPS), was used in this study. The limits of detections of GLYP, GLUF and BIAL w...

An ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) method was developed for simultaneous determination of fifteen constituents in Jitai tablet (JTT), a complex Traditional Chinese Medicine prescription (TCMP) used in treating opiate addiction. Benefitting from a small particle size (1.8 µm) C18 column, accelerated analysis with sat...

A novel thiosemicarbazide-based fluorescent sensor (AFC) was developed. It successfully applied to detect hypochlorite (ClO−) with fluorescence quenching in bis-tris buffer. The limit of detection AFC for ClO− analyzed be 58.7 μM. Importantly, could employed as an efficient and practical water sample zebrafish. Moreover, showed a marked selectivity over varied competitive analytes reactive oxyg...

A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous sample can be well ionized with a high ion intensity. The influence of geometric parameters such as the distance between the two microchannel...

Cosmomycin D (CosD) is the major constituent fraction isolated from a culture of Streptomyces olindensis ICB20. The ability of this compound to intercalate with double-stranded DNA was studied by gel mobility shift assays and electrospray ionization mass spectrometry (ESI-MS). ESI-MS experiments showed that the complex of CosD with 16-mer double-stranded DNA was at least as stable as a complex ...

The development of delayed bitterness in citrus products is a major problem to citrus producers and juice processors worldwide. A rapid and sensitive liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) method has been developed to quantify the recognized precursors of limonoid derived delayed bitterness, limonoate and nomilinoate A-ring lactones, in a wide variety of cit...

Within the past decade, electrospray ionization mass spectrometry (ESI-MS) has rapidly occupied a prominent position for liquid-phase mechanistic studies due to its intrinsic advantages allowing for efficient "fishing" (rapid, sensitive, specific and simultaneous detection/identification) of multiple intermediates and products directly from a "real-world" solution. In this review we attempt to ...

the anthocyanins of the fruit skin of iranian forest pear (sange khouj) were separated, identified and quantified using high-performance liquid chromatography/diode array detection (hplc/dad) and hplc/electrospray ionization /mass spectrometry (hplc/esi /ms). the individual anthocyanins were identified by comparing their mass spectral data and retention times with those of standards and publish...

Experimental modifications that inhibited ionization suppression when using LC-ESI-MS (liquid chromatographyelectrospray ionization-mass spectrometry) in negative ion mode are described for two classes of materials: steroid estrogens and acidic herbicides. Introduction Ionization suppression is a problem when using electrospray ionization (ESI) in negative ion mode. It leads to an apparent redu...