BACKGROUND AND PURPOSE Amyloid-β (Aβ), a peptide that accumulates in the brain and circulates in the blood of patients with Alzheimer disease, alters the regulation of cerebral blood flow and may contribute to the brain dysfunction underlying the dementia. However, the contributions of brain and circulating Aβ1-40 to the vascular dysfunction have not been elucidated. METHODS We used transgeni...

OBJECTIVE Elevated triglyceride (TG) is the major plasma lipid abnormality in obese and diabetic patients and contributes to cardiovascular morbidity in these disorders. We sought to identify novel mechanisms leading to hypertriglyceridemia. Resistance to negative feedback signals from adipose tissue in key central nervous system (CNS) energy homeostatic circuits contributes to the development ...

Background: When whole-body scintigraphy (WBS) is negative despite elevated serum thyroglobulin (Tg) levels, the value of FDG-PET in the diagnosis of recurrent and metastatic thyroid cancer is well documented. An experimental study by Petrich and colleagues (2002) showed that thyrotropin (TSH) levels >0.3 μg/L with equivocal or negative WBS showed an increased level of FDG uptake after recombin...

The antidiabetic effect of various extracts of Desmodium gangeticum (D. gangeticum) was evaluated on normal and streptozotocin (STZ)-nicotinamide induced type-2 diabetic animals. Type-2 diabetes was induced in Wistar albino rats of either sex by the administration of STZ-nicotinamide (40, 110 mg/kg b.w., respectively) intraperitoneally. D. gangeticum (100 mg/kg b.w.) extracts in different solve...

Objective: Background reliable information about the prevalence of dyslipidemia in hypertensive and non hypertensive diabetic patients in local region is essential to the development of regional health policies for prevention and control of this condition. An attempt was made in Puducherry region to examine the lipid profile parameters in the diabetic patients with and without hypertension and ...

IL-1β is believed to play a pathogenic role in the development of pancreatitis. Expression of human IL-1β in pancreatic acinar cells produces chronic pancreatitis, characterized by extensive intrapancreatic inflammation, atrophy, and fibrosis. To determine if activation of trypsinogen is important in the pathogenesis of chronic pancreatitis in this model, we crossed IL-1β transgenic [Tg(IL1β)] ...

The study was undertaken to estimate the lipid profile of university students taking homemade or market fast food frequently. Total 150 male and female students from University College of Medicine and Dentistry, The University of Lahore were included in the study to determine their serum lipid levels e.g. TC, LDL-C, HDL-C and TG. ANOVA test was used for statistical analysis. The 45.03% males an...

OBJECTIVE To examine the effects of chlorogenic acid (CGA) on lipid and glucose metabolism under a high dietary fat burden and to explore the possible role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in these effects. METHODS Twenty male golden hamsters were randomly divided into CGA treatment group (n=10, given peritoneal injection of CGA solution prepared with PBS, 80 m...

Previous studies demonstrated that acute alcohol intoxication caused hepatic lipid accumulation. The present study showed that acute alcohol intoxication caused hepatic lipid accumulation in Tlr4-wild-type mice but not in Tlr4-mutant mice. Hepatic sterol-regulatory element binding protein (SREBP)-1, a transcription factor regulating fatty acid and triglyceride (TG) synthesis, was activated in a...

It is worthwhile to measure serum thyroglobulin (TG) level in thyroid cancer before subjecting patients to surgery for two reasons. Firstly, if the level is high, it may give a clue to the local and metastatic tumour burden at presentation; secondly, if the level is normal, it identifies the patients who are unlikely to show rising TG levels in the presence of thyroid cancer. Those who have hig...