Drug-eluting stents implanted in blood vessels are subject to various dynamics of flow. In this study, we present the evaluation a mathematical model considering effect flow rate, simulate kinetic profiles drug release (Diclofenac Sodium (DS)) from in-vitro PLGA films. This solves set non-linear equation for modeling simultaneously burst, diffusion, swelling and erosion involved mechanisms libe...

BACKGROUND Sirolimus-eluting stents markedly reduce the risk of restenosis compared with bare metal stents. However, it is not known whether there are differences in effectiveness between bare metal and sirolimus-eluting stents in patients with total coronary occlusions. METHODS AND RESULTS In a prospective, randomized, single-blind, 2-center trial, we enrolled 200 patients with total coronar...

At present there is much excitement about drug-eluting stents, which hold promise for the treatment of coronary artery disease. This ingenious therapy involves coating the outside of a standard coronary stent with a thin polymer containing medication that can prevent scarring at the site of coronary intervention. Early trials with sirolimus coated stents showed that they might prevent coronary ...

OBJECTIVES The aim of this study was to evaluate long-term clinical outcomes after percutaneous coronary intervention (PCI) for chronic total occlusions (CTO). BACKGROUND Despite technical advancements, there is a paucity of data on long-term outcomes after PCI of CTO. METHODS We evaluated long-term clinical outcomes in 1,791 patients who underwent PCI of 1,852 CTO at 3 tertiary care center...

BACKGROUND We describe the rationale and design for the 'PercutAneous INTervention with biodegradable-polymer based paclitaxel-eluting or sirolimus-eluting versus bare stents for de novo coronary lesions - PAINT trial'. OBJECTIVES To evaluate two novel formulations of paclitaxel-eluting stent and the sirolimus-eluting stent against a stent with the same metallic structure but without polymer ...

This article contains a review of the most important studies on interventional cardiology reported in either publications or presentations. In the area of coronary interventions, ST-elevation myocardial infarction continues to take center place: recent studies have confirmed the importance of timely intervention and the safety of drug-eluting stents. The numerous studies that have compared diff...

Drug-eluting stents (DES) were introduced in interventional practice more than 10 years ago and rapidly replaced bare-metal stents (BMS) for treatment of coronary artery disease because of their superior capability to reduce the need for restenosis-driven repeat intervention. Soon, it became obvious that besides optimal stenting technique, dual antiplatelet therapy (DAPT), which means the combi...

OBJECTIVES The purpose of this study was to assess trends in endothelial coverage and recovery among leading polymer-based drug-eluting stents (DES). BACKGROUND Autopsy studies of human U.S. Food and Drug Administration (FDA)-approved DES implanted coronary arteries suggest that complications of late stent thrombosis are associated with incomplete endothelial coverage of struts. METHODS Rab...

BACKGROUND Although randomized studies have shown a beneficial effect of drug-eluting stents in reducing the risk of repeated revascularization, these trials were underpowered to compare rates of death and myocardial infarction. The long-term safety of drug-eluting stents has been questioned recently. METHODS We performed a pooled analysis of 1748 patients in four randomized trials evaluating...

BACKGROUND We investigated the pattern of late luminal loss after sirolimus-eluting or bare stent implantation. METHODS AND RESULTS The study population comprised 238 patients treated with sirolimus-eluting stents and 526 patients treated with conventional stents. The distribution of late loss of sirolimus stents was largely skewed to the right and differed from the distribution for bare sten...