background: more than 80% of patients with hematologic  malignancies will develop fever during more than one chemotherapy cycle combined with neutropenia. we aim to evaluate empiric antibiotic strategies in febrile neutropenic (fn) cancer patients. methods: this is a concurrent study performed in the “shahid ghazi” teaching hospital, hematology-oncology center of tabriz, iran during the period ...

Glycoprotein (GP) IIb/IIIa inhibitors are potent antiplatelet agents and represent an exciting breakthrough in the treatment of acute coronary syndromes. However, their safety and cost-effectiveness require further investigation, and more information on risk stratification is needed to clarify which patients benefit the most from empiric use of these agents.

Despite the dramatic decrease in invasive pneumococcal disease since the widespread use of the first pneumococcal vaccine, invasive and resistant disease still occurs. We present a case of ceftriaxone-resistant pneumococcal meningitis suggesting that continued vigilance is warranted for empiric treatment of meningitis when Streptococcus pneumoniae is a concern.

An 11-month-old infant presented with cranial nerve palsy and ataxia. MR revealed a large, enhancing pontine mass and small, nonenhancing parafalcial lesions; no organisms were seen in cerebrospinal fluid. After empiric treatment for brain stem glioma, the patient died. Autopsy revealed meningoencephalitis caused by leptomyxid amebae.

Effective empiric treatment of pneumonia requires antibiotic coverage against gram-negative and gram-positive pathogens, including drug-resistant isolates. We compared the safety and efficacy of intravenous (i.v.) cefepime (2 g administered every 12 h) to those of i.v. ceftriaxone (1 g administered every 12 h) for the empiric treatment of hospitalized patients with community-acquired pneumonia....

We present a case of a woman found to have features concerning for tuberculosis on a screening colonoscopy. Colonic tuberculosis presents with diverse clinical manifestations and resembles other clinical disorders, making its diagnosis challenging. It is imperative to know the classic risk factors and features that define this disease, as empiric treatment is often needed.

BACKGROUND Appropriate empiric therapy, antibiotic therapy with in vitro activity to the infecting organism given prior to confirmed culture results, may improve Staphylococcus aureus outcomes. We aimed to measure the clinical impact of appropriate empiric antibiotic therapy on mortality, while statistically adjusting for comorbidities, severity of illness and presence of virulence factors in t...

Background: The current health care–associated pneumonia (HCAP) model may be too broad, leading to inappropriate use of broad-spectrum antibiotics. As a result, therapeutic algorithms, such aswhatMaruyama et al validated, have been developed for a more specific therapy. Our study aims to validate this algorithm in our patient population. Methods: This is a single-center, prospective, cohort stu...

INTRODUCTION The choice of empiric therapy of acute pyelonephritis (APN) in children should be based on the knowledge of Escherichia coli (E. coli) as the most common uropathogen and its antibiotic sensitivities considering that nowadays ESBL-producing [ESBL (+)] E. coli is on the rise worldwide. OBJECTIVE To examine in vivo susceptibility of ESBL (+) E. coli to ceftriaxone (CTX), and to eval...