5' strand resection at DNA double strand breaks (DSBs) is critical for homologous recombination (HR) and genomic stability. Here we develop a novel method to quantitatively measure single-stranded DNA intermediates in human cells and find that the 5' strand at endonuclease-generated break sites is resected up to 3.5 kb in a cell cycle-dependent manner. Depletion of CtIP, Mre11, Exo1 or SOSS1 bl...

femoral hernias account for 2% to 4% of groin hernias, are more common in women, and are more appropriate to present with strangulation and require emergency surgery. this condition may lead to symptoms of bowel obstruction or strangulation and possible bowel resection-anastomosis. to the best of our knowledge, there is few reports of strangulated femoral hernia. we herein present an 82-year-ol...

The patient was a 90-year-old woman with chief complaints of hemoptysis and wheezing. Cervical computed tomography (CT) scans revealed a mass (2.5x2.0 cm) in the right lobe of the thyroid. The mass was exposed into the tracheal lumen, causing marked stenosis of the airway. When examined by bronchoscopy, the maximal degree of airway stenosis was about 75% of the tracheal cross section. During su...

AIM Because pulpless teeth have a higher risk of vertical root fracture, the present study investigated the additional effect of root end resection upon their mechanical resistence. METHODS Finite element analysis (FEA) was used to evaluate the stress and deformations of upper anterior teeth after root end resection while loading them at 100N and 300N. RESULTS Loading teeth with root end re...

From March 1967 to February 1985 91 patients aged from 11 months to 53 years underwent surgical treatment of isolated coarctation of the aorta. The surgical procedures in descending order of frequency, were: resection with end to end anastomosis, resection with replacement by a tube graft, patch aortoplasty, and bypass graft. Resection with end to end anastomosis was achieved mainly in younger ...

Due to mobility constraints and high dynamics, routing is a more challenging task in VANETs. In this work, we evaluate the performance of the routing protocols in vehicular network environment. The objective of this work is to assess the applicability of these protocols in different vehicular traffic scenarios. Both the position-based and topology-based routing protocols have been considered fo...

mandibular defects may result from many conditions such as trauma, inflammatory diseases and tumors. there are rare cases reported in the literature that have demonstrated spontaneous bone regeneration after resection of the mandible. several factors such as age, preservation of the periosteum and genetics seem to influence spontaneous bone regeneration capacity in individuals. evaluation of th...

Recommendations for anticoagulation following major venous reconstruction for pancreatic adenocarcinoma (PA) are not clearly established. The aim of our study was to find out the relation between postoperative anticoagulant treatment and thrombosis rate after portal venous resection. Materials and methods. Between 1986 and 2006, twenty seven portal vein resections were performed associated with...

Homologous recombination (HR) is initiated by DNA end resection, a process in which stretches of single-strand DNA (ssDNA) are generated and used for homology search. Factors implicated in resection include nucleases MRE11, EXO1, and DNA2, which process DNA ends into 3' ssDNA overhangs; helicases such as BLM, which unwind DNA; and other proteins such as BRCA1 and CtIP whose functions remain unc...