BACKGROUND A good blood supply to the endometrium is usually considered as an essential requirement for implantation. OBJECTIVE The aim of this study was to evaluate the role of endometrial and subendometrial vascularity in the prediction of pregnancy during frozen-thawed embryo transfer (FET) cycles. METHODS Women undergoing FET in natural or clomiphene-induced cycles after the first stimu...

background: despite numerous developments in the field of assisted reproduction the implantation rate remains low .recent studies suggested that local injury to endometrium in controlled ovarian hyper stimulation cycle improves implantation rate. studies have attempted to intervene in the development of endometrium. objective: the aim of the present study was the exploration of the possibility ...

Putative changes in E-cadherin and β-catenin during implantation in dogs are of interest to study, as they are relevant proteins for epithelial integrity. E-cadherin and β-catenin were immunolocalized in the canine endometrium during the estrous cycle and early pregnancy, using monoclonal antibodies. Both proteins were detected in all types of endometrial epithelia (surface epithelium [SE], sup...

STUDY QUESTION How does regulation of telomerase activity (TA) in human endometrial epithelial cells (EEC) by ovarian hormones impact on telomere lengths (TL) and cell proliferation? SUMMARY ANSWER Healthy endometrial epithelial cell proliferation is characterized by high TA and endometrial TL changes according to the ovarian hormone cycle, with shortest TL observed in the progesterone domina...

BACKGROUND Information about lymphatics and lymphangiogenesis in the human endometrium is limited. We investigated the distribution of endometrial lymphatic vessels during the normal menstrual cycle and in association with endometrial adenocarcinoma and investigated the expression of lymphangiogenic growth factors, vascular endothelial growth factor (VEGF)-C, VEGF-D and VEGF receptor-3 (VEGF-R3...

Embryo implantation represents the most critical step of the reproductive process in many species. Inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. The cell adhesion molecule (CAM) such as integrins, cadherins, selectins and immunoglobulins intervene to ensure adhesiveness between the embryo and the endometrium. Some recent studies indicate th...

Recurrent pregnancy loss may be a consequence of an abnormal embryonic karyotype, or maternal factors affecting the endometrium resulting in defective implantation. In order to study the endometrial factors responsible for recurrent pregnancy loss, endometrial biopsy samples should be precisely timed according to the LH surge, and the investigation should be carried out in a non-conception cycl...

objective: in order to evaluate the endometrium by ultrasound in patients undergoing controlled ovarian hyperstimulation (coh) with clomiphene citrate (cc) and human menopausal gonadotropin (hmg) with intrauterine insemination (iui) to determine the relationship between endometrial pattern and thickness on pregnancy rate (pr). methods: in this prospective study, 108 infertile couples underwent ...

background: endometriosis is the presence of endometrial tissue outside of the uterine cavity and is the most common gynecologic disorder in women of reproductive age. we have preliminary evidence that in the presence of a 3-dimensional (3-d) fibrin matrix, human endometrial glands, stroma, and neovascularization can develop in vitro, mimicking the earliest stages of endometriosis. the aim of t...

Nestin, an intermediate filament protein and a stem cell marker is expressed in several tumors. Until recently, little was known about the expression levels and the role of Nestin in endometrial cancer. Compared to the immortalized endometrial epithelial cell line EM-E6/E7-TERT, endometrial cancer cell lines express high to moderate levels of Nestin. Furthermore, endometrial tumors and tumor ce...