Background In patients with abnormal uterine bleeding, transvaginal ultrasound (TVS) is the first-line diagnostic approach to exclude endometrial pathology. If a thickened endometrium suggests endometrial pathology, sonohysterography, office hysteroscopy or dilatation and curettage are the second-line tests preferred, depending on availability and on the suspected pathology, to exclude malignan...

Background: To investigate whether endometrial volume on the day of HCG (human chorionic gonadotropin) administration is a predictor of ART (assisted reproductive outcome) outcome Materials and Methods: Two hundred and seven patients in ART cycle were included in this prospective study; In order to evaluate endometrial volume and its relationship to ART outcome. Endometrial volume obtained from...

OBJECTIVE To describe the endometrial pathologic lesions in premenopausal breast cancer patients with a history of tamoxifen (TMX) use. METHODS We retrospectively reviewed the medical records of 120 premenopausal breast cancer patients with a history of TMX use that had undergone a gynecological examination. RESULTS Among 120 patients, 44.2% (n=53) were asymptomatic with an endometrial thic...

High-mobility group box protein 1 (HMGB1), a nuclear protein that plays a significant role in DNA architecture and transcription, was correlated with the progression of some types of cancer. However, the role of HMGB1 in endometrial cancer cell invasion and metastasis remains unexplored. HMGB1 expression was initially assessed by immunohistochemistry and reverse transcription-quantitative polym...

Bone is a composite organ that fulfils several interconnected functions, which may conflict with each other in pathological conditions. Bone vascularization is at the interface between these functions. The roles of bone vascularization are better documented in bone development, growth and modeling than in bone remodeling. However, every bone remodeling unit is associated with a capillary in bot...

A computerized morphometric investigation of stromal vascularization in the endometrium during adenomyosis was performed retrospectively. Using a polyclonal antibody and a peroxidase-antiperoxidase method, formalin-fixed paraffin sections of the tissue were stained for von Willebrand factor, a marker for endothelium. The subjects were divided into two groups: 42 patients with histologically pro...