Coronary and renal blood flows are important for maintaining cardiac and renal function. Endothelial cells (ECs) play critical roles in forming new vessels and regulating vessel functions. ECs also protect the surrounding tissues by secreting a variety of biologically active substances. Endothelial dysfunction occurs in various forms of cardiovascular and renal diseases. It plays a fundamental ...

Endothelial cells produce various factors that regulate vascular tone, vascular permeability, angiogenesis, and inflammatory responses. The dysfunction of endothelial cells is believed to be the major culprit in various cardiovascular diseases, including hypertension, atherosclerosis, heart and renal failure, coronary syndrome, thrombosis, and diabetes. Endothelial cells express multiple transi...

Endothelial dysfunction and arterial stiffness are major determinants of cardiovascular risk in patients with end-stage renal failure (ESRF). Microparticles are membrane fragments shed from damaged or activated cells. Because microparticles can affect endothelial cells, this study investigated the relationship between circulating microparticles and arterial dysfunction in patients with ESRF and...

BACKGROUND The mechanisms of atrial fibrillation (AF) are highly divergent. The prevalence of AF increases significantly with age, and underling mechanisms might vary with age. Endothelial dysfunction may be associated with AF and atrial arrhythmia recurrence after catheter ablation. We tested the hypothesis that the impact of endothelial dysfunction on arrhythmia recurrence following catheter ...

Nitric oxide (NO) and endothelin (ET) produced in endothelial cells are leading molecules which regulate vascular function. Failure of the physiological balance between these two molecules is usually referred to as endothelial dysfunction. ET was initially identified as a potent vasoconstrictive peptide. Three ET isoforms and two ET receptors have been identified. One of the isoforms, ET-1, pla...

Background and Aim: Preeclampsia is a considerable problem of pregnancy. Endothelial dysfunction and placental hypoxia are the current hypothesis of preeclampsia. Chronic inflammation, including periodontitis may provoke systemic maternal and placental pro-inflammatory endothelial dysfunction, which represent a significant risk factor for diseases of vascular origin. So this study was carried o...

In the development of neuroinflammatory diseases, alterations of the blood brain barrier (BBB) represent key events. The integrity of the BBB is partially maintained by endothelia cells (ECs), since they actively limit the transmigration of immune cells. However, the factors that cause endothelial cells to develop an immune cell-permissive phenotype are poorly understood. In general, it has bee...

Aging is a major risk factor in the development of cardiovascular diseases attributed to the development of vascular endothelial dysfunction. Reduced bioavailability of endothelialnitric oxide (NO) synthase (eNOS) and its product NO is considered the key mechanism mediating reduced endothelial function with aging. Vascular oxidative stress and inflammation increase with age and Western diets ri...

background and aim: preeclampsia is a considerable problem of pregnancy. endothelial dysfunction and placental hypoxia are the current hypothesis of preeclampsia. chronic inflammation, including periodontitis may provoke systemic maternal and placental pro-inflammatory endothelial dysfunction, which represent a significant risk factor for diseases of vascular origin. so this study was carried o...

Diabetes mellitus is associated with an increased risk of cardiovascular disease, even in the presence intensive glycaemic control. Both diabetes and insulin resistance bring about a amalgam endothelial dysfunction it will abate anti-atherogenic role vascular endothelium. In patients type 2 both appear to lead up development undisguised hyperglycaemia. Hence, diabetes, may be censorious early i...